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Invitrogen
Laminin alpha-2 Monoclonal Antibody (CL3450)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-24656
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CL3450
Immunogen
Recombinant protein fragment of Human LAMA2 (Product #RP-108166).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DKLKPIKELE DNLKKNISEI KELINQARKQ ANSIKVSVSS GGDCIRTYKP EIKKGSYNNI VVNVKTAVAD NLLFYLGSAK FIDFLAIEMR KGKVSFLWDV GSGVGRVEYP DLTIDDSYWY RIVASRTGRN GT
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 98%.
Binds to an epitope located within the peptide sequence DKLKPIKELEDNLKK as determined by overlapping synthetic peptides.
Target Information
Laminin is a non-collagenous protein of basement membranes. By rotary shadowing it has a cross-like shape, consisting of one long arm, (400 kD) and three short arms (200 kD). Antibodies to laminin localize exclusively in basement membranes. Laminin is found throughout the basement membrane, but the reaction with the antibodies to laminin is more intense in the lamina lucida, the part of the basement membrane adjacent to the cell membrane. Laminin binds to type IV collagen, a component exclusively localized in the basement membrane. Laminin has been shown to play a role in cell adhesion and attachment in vivo and in vitro.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dystrophia muscularis; laminin alpha-2; laminin M; laminin M chain; laminin, alpha 2; laminin-12 subunit alpha; laminin-2 subunit alpha; laminin-4 subunit alpha; merosin heavy chain; mutant laminin subunit alpha 2; unnamed protein product
Gene Aliases: 5830440B04; dy; LAMM; MDC1A; mer; merosin; mKIAA4087
UniProt ID: (Human) P24043, (Mouse) Q60675
Entrez Gene ID: (Human) 3908, (Rat) 309368, (Mouse) 16773
cell adhesion
axon guidance
organ morphogenesis
tissue development
Schwann cell differentiation
regulation of cell adhesion
regulation of cell migration
regulation of synaptic transmission, cholinergic
positive regulation of synaptic transmission, cholinergic
regulation of embryonic development
signal transduction
nervous system development
muscle organ development
maintenance of blood-brain barrier
positive regulation of cell adhesion
positive regulation of muscle cell differentiation
regulation of basement membrane organization
positive regulation of integrin-mediated signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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