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Invitrogen
PEX5 Monoclonal Antibody (OTI6E9)
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Product Details
MA5-25177
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Non-human primate,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI6E9
Immunogen
Full length human recombinant protein of PEX5 produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
0.57 mg/mL
Amount
57 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Peroxin-5; Peroxisomal C-terminal targeting signal import receptor; peroxisomal import receptor 5; peroxisomal targeting signal 1 (SKL type) receptor; Peroxisomal targeting signal 1 receptor; peroxisomal targeting signal import receptor; peroxisomal targeting signal receptor 1; peroxisome biogenesis factor 5; Peroxisome receptor 1; PTS1 BP; PTS1 receptor; PTS1-BP; unnamed protein product
Gene Aliases: PBD2A; PBD2B; PEX5; Pex5_predicted; PTS1-BP; PTS1R; PXR1; RCDP5
UniProt ID: (Human) P50542, (Rat) Q2M2R8
Entrez Gene ID: (Human) 5830, (Dog) 486710, (Rat) 312703
peroxisome targeting sequence binding
peroxisome matrix targeting signal-1 binding
protein binding
enzyme binding
small GTPase binding
peroxisome membrane targeting sequence binding
protein carrier chaperone
molecular_function
protein C-terminus binding
protein N-terminus binding
membrane trafficking regulatory protein
very long-chain fatty acid metabolic process
pexophagy
neuron migration
protein monoubiquitination
protein targeting to peroxisome
lipid metabolic process
fatty acid beta-oxidation
mitochondrion organization
mitochondrial membrane organization
endoplasmic reticulum organization
peroxisome organization
protein transport
protein import into peroxisome matrix
protein import into peroxisome matrix, docking
protein import into peroxisome matrix, translocation
protein import into peroxisome matrix, receptor recycling
cerebral cortex cell migration
cerebral cortex neuron differentiation
negative regulation of protein complex assembly
cellular response to reactive oxygen species
positive regulation of multicellular organism growth
protein unfolding
protein import into peroxisome matrix, substrate release
protein import into peroxisome membrane
cell development
neuromuscular process
protein tetramerization
biological_process
isoprenoid biosynthetic process
cellular lipid metabolic process
negative regulation of protein homotetramerization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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