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Invitrogen

USP9X Monoclonal Antibody (OTI2G7)

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View all (32) USP9X antibodies

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Product Details

MA5-26367

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Dog, Human, Mouse, Non-human primate, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI2G7

Immunogen

Human recombinant protein fragment corresponding to amino acids 2246-2570 of USP9X produced in E.coli

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2723770

Target Information

USP9X is an ubiquitin-specific protease involved in the removal and recycling of ubiquitin from proteins degraded in proteasomes. As a deubiquitinating enzyme, USP9x has a critical function in tight junction biogenesis by controlling the levels of the exchange factor for Arf6 (EFA6), a protein shown to facilitate tight junction formation during a narrow temporal window preceding the establishment of cell polarity. USP9X is also located on the X-chromosome but escapes X-inactivation, and defects in USP9X may cause gonadal degeneration in Turner syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: deubiquitinating enzyme FAF-X; Drosophila fat facets related, X-linked; fat facets homolog; fat facets in mammals; fat facets protein related, X-linked; fat facets protein-related, X-linked; fat facets-like, X-linked; fats facets protein related, X; probable ubiquitin carboxyl-terminal hydrolase FAF-X; similar to Homo sapiens ubiquitin hydrolase encoded by GenBank Accession Number X98296; ubiquitin carboxyl-terminal hydrolase FAM; ubiquitin specific peptidase 9, X chromosome; ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila); ubiquitin thioesterase FAF-X; ubiquitin thiolesterase FAF-X; ubiquitin-specific processing protease FAF-X; ubiquitin-specific protease 9, X chromosome; ubiquitin-specific-processing protease FAF-X; unknown; unnamed protein product

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Gene Aliases: 5730589N07Rik; DFFRX; FAF; FAF-X; Fafl; FAM; hFAM; MRX99; MRXS99F; RGD1560056; XLID99

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UniProt ID: (Human) Q93008, (Mouse) P70398

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Entrez Gene ID: (Dog) 480885, (Human) 8239, (Rat) 363445, (Mouse) 22284

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Function(s)
cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding cysteine-type peptidase activity Lys63-specific deubiquitinase activity co-SMAD binding ubiquitinyl hydrolase activity molecular sequestering activity K11-linked deubiquitinase activity Lys48-specific deubiquitinase activity ubiquitin protein ligase binding cysteine protease
Process(es)
negative regulation of transcription from RNA polymerase II promoter neuron migration DNA dealkylation involved in DNA repair transforming growth factor beta receptor signaling pathway female gamete generation protein localization cell migration protein import into peroxisome matrix, receptor recycling protein ubiquitination protein deubiquitination BMP signaling pathway regulation of protein stability positive regulation of protein binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process monoubiquitinated protein deubiquitination regulation of circadian rhythm axon extension protein stabilization cilium morphogenesis cytosolic ciliogenesis protein K63-linked deubiquitination protein deubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of TORC2 signaling amyloid fibril formation in utero embryonic development post-embryonic development cerebellar cortex structural organization hippocampus development cellular response to transforming growth factor beta stimulus regulation of postsynapse assembly neuron projection extension protein import into peroxisome matrix regulation of T cell receptor signaling pathway negative regulation of cilium assembly
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