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Invitrogen
Cullin 4B Monoclonal Antibody (OTI7F8)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-26436
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI7F8
Immunogen
Human recombinant protein fragment corresponding to amino acids 1-300 of CUL4B produced in E.coli
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin ligase; Cul4B; ubiquitin E3 ligase; unnamed protein product
Gene Aliases: 2700050M05Rik; CUL-4B; mKIAA0695; MRXHF2; MRXS15; MRXSC; RGD1564494; SFM2
UniProt ID: (Human) Q13620, (Mouse) A2A432
Entrez Gene ID: (Dog) 492102, (Human) 8450, (Rat) 302502, (Mouse) 72584
G1/S transition of mitotic cell cycle
protein polyubiquitination
nucleotide-excision repair
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
spermatogenesis
cell proliferation
gene expression
proteasomal protein catabolic process
regulation of autophagy
protein ubiquitination
regulation of DNA-dependent DNA replication initiation
replication fork processing
regulation of natural killer cell activation
cellular response to UV
regulation of gene expression, epigenetic
regulation of cell proliferation
ribosome biogenesis
regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of embryonic development
astrocyte differentiation
regulation of gene silencing by miRNA
UV-damage excision repair
regulation of cellular response to stress
regulation of cell cycle phase transition
regulation of mitotic cytokinesis
negative regulation of adipose tissue development
regulation of stem cell population maintenance
neuron projection development
positive regulation of protein catabolic process
regulation of protein metabolic process
positive regulation of G1/S transition of mitotic cell cycle
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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