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Invitrogen

MyD88 Recombinant Rabbit Monoclonal Antibody (RM306)

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MyD88 Recombinant Rabbit Monoclonal Antibody (RM306)

Product Details

MA5-27972

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:250
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

RM306

Immunogen

A peptide corresponding to the N-terminus of human MyD88
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Amount

5 µg

Purification

Protein A

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2744987

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Myeloid differentiation Marker 88 (MyD88) is an adaptor molecule for the Toll/IL-1R and is involved in the inflammatory response induced by IL-1, IL-18 and LPS. MyD88 recruits IRAK to IL-1 receptor complex in response to IL-1. This pathway further leads to activation of NF-kB. MyD88 has a wide tissue distribution.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: mutant myeloid differentiation primary response 88; myeloid differentiation primary response 88; myeloid differentiation primary response gene (88); myleoid differentiation primary response protein; TLR adaptor MYD88; unnamed protein product

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Gene Aliases: IMD68; MYD88D; WM1

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UniProt ID: (Human) Q99836

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Entrez Gene ID: (Human) 4615

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Function(s)
receptor binding Toll binding death receptor binding cytokine receptor binding interleukin-1 receptor binding protein binding Toll-like receptor binding signaling adaptor activity identical protein binding binding, bridging TIR domain binding ATP-dependent histone chaperone activity
Process(es)
toll-like receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway chromatin organization chromatin remodeling phagocytosis apoptotic process signal transduction cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling JNK cascade Toll signaling pathway gene expression positive regulation of gene expression response to amine cytokine-mediated signaling pathway lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production positive regulation of interleukin-1 beta production positive regulation of interleukin-17 production positive regulation of interleukin-23 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production toll-like receptor 4 signaling pathway toll-like receptor 5 signaling pathway toll-like receptor 8 signaling pathway toll-like receptor 9 signaling pathway toll-like receptor TLR6:TLR2 signaling pathway interleukin-33-mediated signaling pathway defense response to bacterium defense response to protozoan positive regulation of I-kappaB kinase/NF-kappaB signaling response to amino acid regulation of MAP kinase activity skin development NLRP3 inflammasome complex assembly innate immune response response to ethanol positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle cell proliferation regulation of inflammatory response defense response to Gram-positive bacterium defense response to virus type I interferon signaling pathway interleukin-1-mediated signaling pathway response to interleukin-1 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to oxidised low-density lipoprotein particle stimulus positive regulation of cytokine production involved in inflammatory response positive regulation of NLRP3 inflammasome complex assembly
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