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Invitrogen
Caspr2 Recombinant Rabbit Monoclonal Antibody (001)
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Product Details
MA5-29190
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
001
Immunogen
Recombinant Mouse CNTNAP2/CASPR2 protein (Met1-Ser1262)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse CNTNAP2/CASPR2.
Target Information
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell recognition molecule Caspr2; DKFZp781D1846; unnamed protein product
Gene Aliases: 5430425M22Rik; Caspr2; mKIAA0868
UniProt ID: (Mouse) Q9CPW0
Entrez Gene ID: (Mouse) 66797
cell morphogenesis
in utero embryonic development
startle response
response to dietary excess
inflammatory response
mitochondrion organization
cell adhesion
signal transduction
chemical synaptic transmission
nervous system development
axonogenesis
central nervous system development
learning
rhythmic behavior
grooming behavior
locomotory behavior
neuron recognition
protein localization
cell proliferation
associative learning
response to heat
response to xenobiotic stimulus
response to mechanical stimulus
response to light intensity
response to hormone
gene expression
glial cell proliferation
transmission of nerve impulse
neuronal action potential
cerebellum development
cerebellar Purkinje cell layer morphogenesis
limbic system development
central nervous system myelination
neuron differentiation
adult behavior
neuron projection development
TOR signaling
regulation of synaptic transmission, GABAergic
negative regulation of synaptic transmission, GABAergic
cell junction assembly
cell junction maintenance
social behavior
multicellular organism growth
intracellular signal transduction
vocal learning
myelination
circadian sleep/wake cycle
clustering of voltage-gated potassium channels
fat cell differentiation
locomotor rhythm
response to pain
behavioral response to pain
neuron projection morphogenesis
neuromuscular process controlling posture
neuromuscular process
negative regulation of protein kinase B signaling
excitatory postsynaptic potential
prepulse inhibition
dendritic spine development
neural precursor cell proliferation
motor behavior
ERK1 and ERK2 cascade
protein localization to juxtaparanode region of axon
vocalization behavior
walking behavior
dendritic spine organization
dendritic spine maintenance
postsynaptic density organization
response to interleukin-17
neuromuscular junction development, skeletal muscle fiber
excitatory chemical synaptic transmission
inhibitory chemical synaptic transmission
regulation of postsynaptic membrane neurotransmitter receptor levels
maintenance of synapse structure
action potential initiation
dendrite arborization
response to metformin
positive regulation of gap junction assembly
negative regulation of neuronal action potential
positive regulation of neuronal action potential
excitatory synapse assembly
inhibitory synapse assembly
glutamatergic neuron differentiation
embryonic brain development
response to odorant
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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