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Invitrogen
AGTR2 Recombinant Rabbit Monoclonal Antibody (SN71-03)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-32293
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SN71-03
Immunogen
Synthetic peptide within Human Angiotensin II Type 2 Receptoraa 311-363.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AGTR2; Angiotensin ii at2; angiotensin II type 2 receptor; angiotensin II type-2 receptor; angiotensin receptor 2; AT2; AT2 receptor; unnamed protein product
Gene Aliases: AT2; AT2-R; AT2R; AT2R; ATGR2; MRX88
UniProt ID: (Human) P50052, (Rat) P35351, (Mouse) P35374
Entrez Gene ID: (Human) 186, (Rat) 24182, (Mouse) 11609
blood vessel remodeling
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
inflammatory response
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
brain development
regulation of blood pressure
negative regulation of heart rate
negative regulation of cell growth
regulation of metanephros size
exploration behavior
nitric oxide-cGMP-mediated signaling pathway
angiotensin-activated signaling pathway
vasodilation
regulation of apoptotic process
negative regulation of blood vessel endothelial cell migration
positive regulation of transcription, DNA-templated
negative regulation of neurotrophin TRK receptor signaling pathway
positive regulation of metanephric glomerulus development
positive regulation of branching involved in ureteric bud morphogenesis
regulation of blood vessel diameter
positive regulation of extrinsic apoptotic signaling pathway
positive regulation of cytokine production
kidney development
regulation of blood volume by renin-angiotensin
renin-angiotensin regulation of aldosterone production
brain renin-angiotensin system
renal system process involved in regulation of systemic arterial blood pressure
cellular sodium ion homeostasis
positive regulation of cell proliferation
negative regulation of norepinephrine secretion
cerebellar cortex development
neuron differentiation
negative regulation of icosanoid secretion
regulation of protein import into nucleus
dopamine biosynthetic process
negative regulation of fibroblast proliferation
kidney morphogenesis
cell growth involved in cardiac muscle cell development
cellular response to dexamethasone stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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