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Invitrogen

Abl2 Recombinant Rabbit Monoclonal Antibody (JF0951)

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Abl2 Recombinant Rabbit Monoclonal Antibody (JF0951)

Product Details

MA5-32501

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JF0951

Immunogen

Synthetic peptide within Human ABL2 aa 502-552.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809778

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

ABL2 (Arg) is an Abl-related non-receptor protein tyrosine kinase that links cell surface receptors to cell proliferation and/or cytoskeletal reorganization. Abl2 encodes a member of the Abelson family of nonreceptor tyrosine protein kinase. The protein is highly similar to the ABL1 protein, including the tyrosine kinase, SH2 and SH3 domains, and has a role in cytoskeletal rearrangements by its C-terminal F-actin- and microtubule-binding sequences. Abl2 is expressed in both normal and tumor cells, and is involved in translocation with the ETV6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Abelson murine leukemia viral (v-abl) oncogene homolog 2; abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; Abl1-related gene product; arg tyrosine kinase; c-abl oncogene 2, non-receptor tyrosine kinase; FLJ22224; FLJ31718; FLJ41441; nonreceptor tyrosine kinase; tyrosine kinase ARG; tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene 2; v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene); v-abl Abelson murine leukemia viral oncogene homolog 2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

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Gene Aliases: ABLL; ARG

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UniProt ID: (Human) P42684

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Entrez Gene ID: (Human) 27, (Mouse) 11352, (Rat) 304883

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Function(s)
magnesium ion binding phosphotyrosine binding actin monomer binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity protein binding ATP binding enzyme activator activity enzyme binding manganese ion binding actin filament binding nucleotide binding
Process(es)
signal transduction epidermal growth factor receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration regulation of autophagy positive regulation of neuron projection development peptidyl-tyrosine phosphorylation regulation of endocytosis regulation of cell adhesion regulation of actin cytoskeleton organization cellular response to oxidative stress negative regulation of Rho protein signal transduction exploration behavior protein modification process cellular response to retinoic acid positive regulation of establishment of T cell polarity regulation of cell motility positive regulation of T cell migration neural tube closure aggressive behavior protein phosphorylation phagocytosis substrate-dependent cell migration, cell extension actin filament organization learning adult walking behavior protein localization visual learning post-embryonic development neuron remodeling cerebellum morphogenesis negative regulation of cell-cell adhesion actin cytoskeleton organization neuron differentiation auditory behavior positive regulation of interferon-gamma production positive regulation of interleukin-2 production multicellular organism growth positive regulation of I-kappaB kinase/NF-kappaB signaling alpha-beta T cell differentiation platelet-derived growth factor receptor signaling pathway dendrite morphogenesis neuromuscular process controlling balance actin filament bundle assembly Bergmann glial cell differentiation synapse maturation neuroepithelial cell differentiation positive regulation of ERK1 and ERK2 cascade circulatory system development dendritic spine maintenance plasma membrane bounded cell projection assembly negative regulation of intracellular signal transduction regulation of extracellular matrix organization positive regulation of Wnt signaling pathway, planar cell polarity pathway negative regulation of endothelial cell apoptotic process biological_process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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