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Invitrogen
GATA6 Monoclonal Antibody (6H8)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-32961
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Monoclonal
Type
Antibody
Clone
6H8
Immunogen
Recombinant full length Human GATA-6.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
The GATA6 gene encodes a member of the GATA family of zinc-finger transcription factors, which are critical in regulating gene expression during development. GATA6 plays a crucial role in the differentiation and development of multiple tissues, including the heart and gastrointestinal tract, by interacting with other transcriptional regulators through its zinc-finger domains. This gene influences signaling pathways that drive epithelial-to-mesenchymal transitions (EMTs) and immune surveillance, which are essential processes in maintaining tissue homeostasis and countering tumor progression. In the respiratory tract, GATA6 is essential for the differentiation of lung epithelial cells, impacting the expression of WNT7B and surfactant proteins, vital for proper lung function. Furthermore, studies suggest that GATA6 contributes to an immune-enriched phenotype linked to favorable prognostic outcomes in certain cancers, indicating its potential role in mitigating metastatic propensity by enhancing immune response and surveillance against tumorous cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ASD9; AVSD5; GATA-binding factor 6
UniProt ID: (Human) Q92908
Entrez Gene ID: (Human) 2627
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription coactivator binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
protein kinase binding
sequence-specific DNA binding
NFAT protein binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
sebaceous gland cell differentiation
regulation of antimicrobial humoral response
outflow tract septum morphogenesis
atrioventricular node development
sinoatrial node development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
male gonad development
response to xenobiotic stimulus
anatomical structure morphogenesis
gene expression
cell differentiation
epithelial cell differentiation
response to retinoic acid
negative regulation of transforming growth factor beta1 production
negative regulation of transforming growth factor beta2 production
atrioventricular canal development
negative regulation of apoptotic process
cell fate commitment
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
animal organ development
system development
smooth muscle cell differentiation
heart contraction
intestinal epithelial cell differentiation
cardiac vascular smooth muscle cell differentiation
G1 to G0 transition involved in cell differentiation
response to growth factor
cellular response to hypoxia
skin epidermis development
positive regulation of cardiac muscle myoblast proliferation
negative regulation of sebum secreting cell proliferation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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