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Invitrogen
MYH7 Monoclonal Antibody (NOQ7.5.4D)
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FIGURE: 1 / 5
MYH7 Antibody (MA5-32986) in IHC (P)
Immunohistochemistry (Paraffin) analysis of MYH7 in paraffin-embedded section of rat skeletal muscle tissue using MYH7 Monoclonal Antibody (NOQ7.5.4D) (Product # MA5-32986). Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody at a 2 µg/mL dilution... View More
Product Details
MA5-32986
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
NOQ7.5.4D
Immunogen
Human skeletal muscle myosin purified from myofibrils.
Conjugate
Form
Lyophilized
Concentration
100 µg/mL
Amount
100 µg
Storage buffer
ascites/1.2% sodium acetate with 2mg BSA
Contains
0.01mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 1 mL of PBS buffer to yield a concentration of 100 µg/mL.
Positive Control - WB: rat heart tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: beta myosin heavy chain; beta-myosin heavy chain; cardiac muscle myosin heavy chain 7 beta; cardiac myosin heavy chain beta isoform; MYH-beta/slow; MyHC-beta; MyHC-slow; myosin 7; myosin heavy chain; Myosin heavy chain 7; myosin heavy chain beta-subunit; myosin heavy chain MYH7; muscle filament; myosin heavy chain polypeptide 7 cardiac muscle fetal; Myosin heavy chain slow isoform; Myosin heavy chain, cardiac muscle beta isoform; myosin heavy chain, cardiac muscle, fetal; myosin heavy chain, polypeptide 7; myosin, heavy chain 7, cardiac muscle, beta; myosin, heavy polypeptide 7, cardiac muscle, beta; Myosin-7; rhabdomyosarcoma antigen MU-RMS-40.7A; sarcomeric protein; unnamed protein product
Gene Aliases: B-MHC; beta-MHC; CMD1S; CMH1; CMYO7A; CMYO7B; CMYP7A; CMYP7B; MPD1; MYH7; Myhc-b; MyHC-I; MYHCB; SPMD; SPMM
UniProt ID: (Human) P12883, (Mouse) Q91Z83, (Rat) P02564
Entrez Gene ID: (Human) 4625, (Mouse) 140781, (Rat) 29557
microfilament motor activity
nucleotide binding
motor activity
actin binding
protein binding
calmodulin binding
ATP binding
actin filament binding
ATPase activity
actin-dependent ATPase activity
protein homodimerization activity
protein heterodimerization activity
non-receptor serine/threonine protein kinase
regulation of the force of heart contraction
regulation of heart rate
skeletal muscle contraction
muscle contraction
striated muscle contraction
adult heart development
regulation of the force of skeletal muscle contraction
transition between fast and slow fiber
cardiac muscle hypertrophy in response to stress
muscle filament sliding
regulation of slow-twitch skeletal muscle fiber contraction
ATP metabolic process
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
metabolic process
response to reactive oxygen species
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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