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FIGURE: 1 / 6
LRP1 Antibody (MA5-35053) in ICC/IF
Immunofluorescence of LRP1 was performed using HAP1 WT and HAP1 LRP1 KO cells that were labeled with a green or a far-red fluorescent dye, respectively. WT and KO cells were mixed and plated to a 1:1 ratio on glass coverslips as a mosaic and incubated for 24 hrs. Cells were fixed in 4% PFA (in PBS) for 15 min at RT; cells were permeabilized with 0.1% Triton X-100 for 10 min at RT and blocked with PBS containing 5% BSA, 5% goat serum, and 0.01% Triton X-100 for 30 min. Cells were stained with LRP1 Recombinant Rabbit Monoclonal Antibody (ARC... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-35053
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4O3Y8
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PPHMTGPRCE EHVFSQQQPG HIASILIPLL LLLLLVLVAG VVFWYKRRVQ GAKGFQHQRM TNGAMNVEIG NPTYKMYEGG EPDDVGGLLD ADFALDPDKP T
Target Information
CD91 is a 600 kDa type I transmembrane protein composed of an alpha and beta chain. The alpha chain interacts with a variety of structurally and functionally diverse ligands, while the beta chain contains two tyrosine phosphorylation motifs that interact with adaptor and signaling proteins. This receptor is expressed by cells in the monocytic lineage, dendritic cells, hepatocytes, fibroblasts, adipocytes, neurons, and syncytiotrophoblasts. CD91 plays a crucial role in several cellular processes, including ligand endocytosis and trafficking to lysosomes, intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. It is involved in cross-presenting antigens via MHC class I molecules on antigen-presenting cells after endocytosis of heat shock protein-peptide complexes. Additionally, CD91 is essential for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of CD91 decreases with age and is found to be lower in brain tissue from Alzheimer patients compared to controls. The receptor also plays a role in cell migration and activating signaling cascades, highlighting its importance in both immune function and disease processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha 2-macroglobulin receptor; alpha-2-macroglobulin receptor; apolipoprotein E receptor; cell surface receptor; FLJ16451; lipoprotein receptor-related protein; low density lipoprotein receptor-related protein 1; low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor); LRP-1; MGC88725; TbetaR-V/LRP-1/IGFBP-3 receptor; type V tgf-beta receptor; unnamed protein product
Gene Aliases: A2MR; APOER; APR; b2b1554Clo; CD91; DDH3; IGFBP-3R; IGFBP3R; IGFBP3R1; KPA; LRP; LRP-1; LRP1A; TGFBR5
UniProt ID: (Human) Q07954, (Mouse) Q91ZX7, (Rat) G3V928
Entrez Gene ID: (Human) 4035, (Mouse) 16971, (Rat) 299858
beta-amyloid binding
virus receptor activity
RNA binding
low-density lipoprotein receptor activity
scavenger receptor activity
calcium ion binding
protein binding
alpha-2 macroglobulin receptor activity
apolipoprotein receptor activity
clathrin heavy chain binding
apolipoprotein binding
signaling receptor activity
cargo receptor activity
heparan sulfate proteoglycan binding
macromolecular complex binding
lipoprotein particle receptor binding
protease binding
receptor binding
coreceptor activity
protein serine/threonine kinase binding
astrocyte activation involved in immune response
outflow tract morphogenesis
atrioventricular valve development
cardiac septum development
receptor-mediated endocytosis
phagocytosis
apoptotic process
lysosomal transport
enzyme linked receptor protein signaling pathway
transforming growth factor beta receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
heart development
cholesterol metabolic process
cell proliferation
gene expression
negative regulation of gene expression
negative regulation of cell-substrate adhesion
positive regulation of cholesterol efflux
positive regulation of neuron projection development
negative regulation of neuron projection development
regulation of smooth muscle cell migration
negative regulation of smooth muscle cell migration
cell migration
regulation of endocytosis
negative regulation of Wnt signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
receptor internalization
positive regulation of lipid transport
positive regulation of cholesterol transport
regulation of actin cytoskeleton organization
positive regulation of insulin secretion involved in cellular response to glucose stimulus
aorta development
aorta morphogenesis
negative regulation of apoptotic process
apoptotic cell clearance
negative regulation of neuron apoptotic process
positive regulation of axon extension
positive regulation of endocytosis
viral entry into host cell
positive regulation of axon extension involved in regeneration
positive regulation of collateral sprouting of injured axon
cell motility
positive regulation of phagocytosis
positive regulation of protein transport
negative regulation of cytosolic calcium ion concentration
negative regulation of focal adhesion assembly
negative regulation of SMAD protein import into nucleus
coronary vasculature development
chemoattraction of axon
positive regulation of ERK1 and ERK2 cascade
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
beta-amyloid clearance
regulation of postsynaptic neurotransmitter receptor internalization
amyloid-beta clearance by transcytosis
amyloid-beta clearance by cellular catabolic process
transport across blood-brain barrier
positive regulation of Schwann cell migration
positive regulation of beta-amyloid clearance
regulation of extracellular matrix organization
positive regulation of reverse cholesterol transport
positive regulation of protein localization to plasma membrane
positive regulation of cholesterol import
positive regulation of transcytosis
cellular response to beta-amyloid
positive regulation of vascular associated smooth muscle cell migration
regulation of pulmonary blood vessel remodeling
positive regulation of lysosomal protein catabolic process
positive regulation of chemokine (C-X-C motif) ligand 2 production
negative regulation of platelet-derived growth factor receptor-beta signaling pathway
cerebral cortex development
negative regulation of thrombin receptor signaling pathway
retinoid metabolic process
lipid metabolic process
regulation of extracellular matrix disassembly
lipoprotein transport
transcytosis
positive regulation of transport
regulation of protein metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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