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Invitrogen
FANCD2 Recombinant Rabbit Monoclonal Antibody (7U2D6)
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FIGURE: 1 / 4
FANCD2 Antibody (MA5-35344) in WB
Western blot analysis of FANCD2 in extracts of various cell lines. Samples were incubated with FANCD2 Monoclonal antibody (Product # MA5-35344) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-35344
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
7U2D6
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.375 mg/mL
Amount
37.5 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ISIAPENLQH DIITSLPEIL GDSQHADVGK ELSDLLIENT SLTVPILDVL SSLRLDPNFL LKVRQLVMDK LSSIRLEDLP VIIKFILHSV TAMDTLEVIS E
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin. Defects in the FANCD2 gene result in Fanconi anemia complementation group D2. This disorder affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp762A223; FACD2; Fanconi anemia complementation group D2; Fanconi anemia D2 protein; Fanconi anemia, complementation group D2; FLJ23826; unnamed protein product
Gene Aliases: 2410150O07Rik; FA-D2; FA4; FACD; FAD; FAD2; FANCD
UniProt ID: (Human) Q9BXW9, (Rat) Q6IV68, (Mouse) Q80V62
Entrez Gene ID: (Human) 2177, (Rat) 312641, (Mouse) 211651
DNA repair
synapsis
response to gamma radiation
intra-S DNA damage checkpoint
interstrand cross-link repair
double-strand break repair involved in meiotic recombination
cellular response to DNA damage stimulus
gamete generation
biological_process
cellular response to oxidative stress
regulation of regulatory T cell differentiation
brain morphogenesis
regulation of inflammatory response
neuronal stem cell population maintenance
regulation of CD40 signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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