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Invitrogen

IKAROS Recombinant Rabbit Monoclonal Antibody (4S10I3)

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IKAROS Recombinant Rabbit Monoclonal Antibody (4S10I3)

Product Details

MA5-35380

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-

ChIP assay (ChIP)

5 µg antibody for 10 µg-15 µg of Chromatin
-

CUT&RUN (CUT&RUN)

1x10^5 cells /1 µg
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4S10I3

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 250-350 of human Ikaros (Q13422)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849281

Product Specific Information

Immunogen sequence: AEDLCKIGSE RSLVLDRLAS NVAKRKSSMP QKFLGDKGLS DTPYDSSASY EKENEMMKSH VMDQAINNAI NYLGAESLRP LVQTPPGGSE VVPVISPMYQ L

Target Information

DNA-binding protein IKAROS functions in the specification and the maturation of the T lymphocyte. It also interacts with a critical control element in the terminal deoxynucleotidyl transferase promoter as well as with the promoters for other genes expressed during early stages of B-cell and T-cell development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CLL-associated antigen KW-6; hIk-1; ikaros family zinc finger protein 1; Ikaros zinc finger protein; zinc finger protein subfamily 1A 1; DNA-binding protein Ikaros; CLL-associated antigen KW-6; Ikaros family zinc finger protein 1; lymphoid transcription factor LyF-1; lymphocyte-restricted zinc finger DNA binding protein; lymphoid transcription factor LyF-1; predicted protein of HQ0758; protein phosphatase 1, regulatory subunit 92; transcription factor activity; Ikaros; Zfpn1a1; Ik11; unnamed protein product; zinc finger protein, subfamily 1A, 1 (Ikaros); zinc finger transcription factor

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Gene Aliases: 5832432G11Rik; CVID13; hlk-1; Hs.54452; IK1; IKAROS; LyF-1; LYF1; mKIAA4227; PPP1R92; PRO0758; Zfpn1a1; ZNFN1A1

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UniProt ID: (Human) Q13422

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Entrez Gene ID: (Human) 10320, (Mouse) 22778

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein domain specific binding identical protein binding transcription regulatory region sequence-specific DNA binding poly-pyrimidine tract binding sequence-specific DNA binding
Process(es)
regulation of transcription from RNA polymerase II promoter mesoderm development lymphocyte differentiation erythrocyte differentiation negative regulation of transcription, DNA-templated negative regulation of transcription from RNA polymerase II promoter natural killer cell differentiation regulation of transcription, DNA-templated positive regulation of gene expression hemopoiesis B cell differentiation T cell differentiation forebrain development positive regulation of transcription elongation from RNA polymerase II promoter amacrine cell differentiation positive regulation of multicellular organism growth establishment of protein localization regulation of lymphocyte differentiation positive regulation of neutrophil differentiation positive regulation of transcription, DNA-templated positive regulation of RNA polymerase II transcriptional preinitiation complex assembly positive regulation of transcription from RNA polymerase II promoter lymph node development thymus development Peyer's patch development gland development positive regulation of NK T cell differentiation retinal bipolar neuron differentiation retina development in camera-type eye
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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