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Invitrogen
SGK1 Recombinant Rabbit Monoclonal Antibody (3P4N3)
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FIGURE: 1 / 1
SGK1 Antibody (MA5-35420) in WB
Western blot analysis of SGK1 in extracts of various cell lines. Samples were incubated with SGK1 Monoclonal antibody (Product # MA5-35420) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3 min.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-35420
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
3P4N3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SGK1 (O00141)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.06 mg/mL
Amount
106 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MTVKTEAAKG TLTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK HPEVQSILKI SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF
Target Information
SGK (SGK1) is a serine/threonine kinase that may be a transcriptional target for p38/MAPK in hepatoma cells. SGK plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: N-terminal variant of classic Sgk1; serine/threonine kinase; serine/threonine protein kinase SGK; serum and glucocorticoid-dependent protein kinase; Sgk1_i2; unnamed protein product
Gene Aliases: SGK
UniProt ID: (Human) O00141, (Mouse) Q9WVC6
Entrez Gene ID: (Human) 6446, (Mouse) 20393
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
calcium channel regulator activity
protein binding
ATP binding
potassium channel regulator activity
sodium channel regulator activity
chloride channel regulator activity
protein serine kinase activity
3-phosphoinositide-dependent protein kinase binding
tau protein binding
protein phosphorylation
cellular sodium ion homeostasis
cellular response to DNA damage stimulus
microtubule depolymerization
signal transduction
long-term memory
visual learning
positive regulation of sodium ion transport
peptidyl-serine phosphorylation
positive regulation of cell growth
negative regulation of microtubule polymerization
cellular response to insulin stimulus
regulation of protein localization
intracellular signal transduction
negative regulation of apoptotic process
neuron projection morphogenesis
positive regulation of dendrite morphogenesis
cellular response to aldosterone
regulation of blood pressure
renal sodium ion absorption
regulation of signal transduction by p53 class mediator
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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