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Invitrogen
FDFT1 Recombinant Rabbit Monoclonal Antibody (4W10J4)
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FIGURE: 1 / 2
FDFT1 Antibody (MA5-35552) in WB
Western blot analysis of FDFT1 in extracts of various cell lines. Samples were incubated with FDFT1 Monoclonal antibody (Product # MA5-35552) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-35552
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4W10J4
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SQS/FDFT1 (P37268)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.5 mg/mL
Amount
150 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MGIGMAEFLD KHVTSEQEWD KYCHYVAGLV GIGLSRLFSA SEFEDPLVGE DTERANSMGL FLQKTNIIRD YLEDQQGGRE FWPQEVWSRY VKKLGDFAKP E
Target Information
FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: farnesyl diphosphate farnesyltransferase; farnesyl diphosphate:farnesyl diphosphate farnesyltransferase; farnesyl-diphosphate farnesyltransferase; FDFT1; FPP:FPP farnesyltransferase; presqualene-di-diphosphate synthase; SQS; squalene synthetase; SS; unnamed protein product
Gene Aliases: DGPT; ERG9; SQS; SQSD; SS
UniProt ID: (Human) P37268, (Mouse) P53798, (Rat) Q02769
Entrez Gene ID: (Human) 2222, (Mouse) 14137, (Rat) 29580
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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