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Invitrogen
SF3B3 Recombinant Rabbit Monoclonal Antibody (3K1X4)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-35823
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
3K1X4
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1101-1217 of human SF3B3/SAP130 (Q15393)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.9 mg/mL
Amount
90 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VLSLQKTTLI PGGSESLVYT TLSGGIGILV PFTSHEDHDF FQHVEMHLRS EHPPLCGRDH LSFRSYYFPV KNVIDGDLCE QFNSMEPNKQ KNVSEELDRT PPEVSKKLED IRTRYAF
Target Information
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex transcription coactivator-HAT complex, and the TFTC -containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KIAA0017; pre-mRNA splicing factor SF3b, 130 kDa subunit; pre-mRNA-splicing factor SF3b 130 kDa subunit; SAP 130; spliceosome-associated protein 130; unnamed protein product
Gene Aliases: 1810061H24Rik; 5730409A01Rik; D8Ertd633e; mKIAA0017; RSE1; SAP130; SF3b130; STAF130
UniProt ID: (Human) Q15393, (Mouse) Q921M3
Entrez Gene ID: (Human) 23450, (Mouse) 101943, (Rat) 292019
mRNA splicing, via spliceosome
regulation of DNA repair
negative regulation of protein catabolic process
regulation of RNA splicing
positive regulation of transcription, DNA-templated
biological_process
RNA splicing, via transesterification reactions
spliceosomal snRNP assembly
spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
RNA splicing
U2-type prespliceosome assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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