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Oxytocin Receptor Recombinant Rabbit Monoclonal Antibody (7X8B8)

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Oxytocin Receptor Recombinant Rabbit Monoclonal Antibody (7X8B8)

Product Details

MA5-37974

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

7X8B8

Immunogen

Synthetic peptide
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.2 mg/mL

Amount

120 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897892

Product Specific Information

Positive Samples: HeLa, PC-3, Jukat, Mouse brain

Immunogen sequence: LLLALSGNAC VLLALRTTRQ KHSRLFFFMK HLSIADLVVA VFQVLPQLLW DITFRFYGPD LLCRLVKYLQ VVGMFASTYL LLLMSLDRCL AICQPLRSLR R

Target Information

The oxytocin receptor (OXTR) belongs to the G-protein coupled receptor family. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The receptor is made up of 389 amino acids and has a molecular weight of ~43,000 kDa. The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection. Oxytocin receptors are expressed by the myoepithelial cells of the mammary gland, and in both the myometrium and endometrium or the uterus at the end of pregnancy. Additionally, oxytocin receptors are present in the central nervous system, mediating a variety of behaviors, including maternal behavior, bonding, social memory and recognition, sexual and aggressive behaviors, and stress and anxiety.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: G-protein coupled receptor; OT-R; oxcytocin receptor; Oxt-r; OXTR; unnamed protein product

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Gene Aliases: OT-R; OTR; OTR1

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UniProt ID: (Human) P30559, (Mouse) P97926, (Rat) P70536

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Entrez Gene ID: (Human) 5021, (Mouse) 18430, (Rat) 25342

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Function(s)
G-protein coupled receptor activity oxytocin receptor activity vasopressin receptor activity peptide hormone binding ionotropic glutamate receptor binding protein binding
Process(es)
suckling behavior response to amphetamine regulation of systemic arterial blood pressure by vasopressin system process G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration female pregnancy memory positive regulation of norepinephrine secretion positive regulation of synaptic transmission, GABAergic cellular response to hormone stimulus response to anoxia social behavior maternal behavior sperm ejaculation eating behavior positive regulation of osteoblast differentiation positive regulation of blood pressure positive regulation of vasoconstriction regulation of synaptic plasticity response to steroid hormone positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic maternal process involved in parturition fetal process involved in parturition milk ejection female mating behavior positive regulation of penile erection ERK1 and ERK2 cascade positive regulation of uterine smooth muscle contraction positive regulation of cold-induced thermogenesis heart development response to xenobiotic stimulus telencephalon development response to estradiol response to progesterone response to genistein response to cytokine response to cocaine response to peptide hormone estrous cycle digestive tract development response to phorbol 13-acetate 12-myristate muscle contraction cell surface receptor signaling pathway lactation
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