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Invitrogen
TNPO3 Recombinant Rabbit Monoclonal Antibody (0U3Q1)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-37991
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
0U3Q1
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.13 mg/mL
Amount
113 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: HeLa, RD, Jurkat, Mouse lung, Mouse testis, Mouse thymus, Rat testis
Immunogen sequence: QVMNQLGQQL VSQLLHTCCF CLPPYTLPDV AEVLWEIMQV DRPTFCRWLE NSLKGLPKET TVGAVTVTHK QLTDFHKQVT SAEECKQVCW ALRDFTRLFR
Target Information
TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: imp12; importin 12; limb girdle muscular dystrophy 1F (autosomal dominant); This CDS feature is included to show the translation of the corresponding V_region. Presently translation qualifiers on V_region features are illegal.; transportin-SR; unnamed protein product
Gene Aliases: 5730544L10Rik; C430013M08Rik; D6Ertd313e; IPO12; LGMD1F; LGMDD2; mKIAA4133; MTR10A; TRN-SR; TRN-SR2; TRNSR
UniProt ID: (Human) Q9Y5L0, (Mouse) Q6P2B1
Entrez Gene ID: (Human) 23534, (Rat) 296954, (Mouse) 320938
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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