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Invitrogen
ACVR1B Recombinant Rabbit Monoclonal Antibody (3U6I8)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-38039
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
3U6I8
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.18 mg/mL
Amount
118 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: 293T, HepG2, U-87MG, Mouse brain, Rat brain
Immunogen sequence: MAESAGASSF FPLVVLLLAG SGGSGPRGVQ ALLCACTSCL QANYTCETDG ACMVSIFNLD GMEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYTDY
Target Information
ACVR1B is a serine/threonine kinase involved in signal transduction and cellular communication. Several truncated ACVR1B isoforms have been reported to be exclusively expressed in human pituitary tumors. Mutations of ACVR1B have been observed in pancreatic adenocarcinomas. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1B encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor, type IB; activin A receptor, type II-like kinase 4; activin receptor type IB; activin receptor-like kinase 4; ACTR-IB; ACTRI; ACVR1A; ACVRLK2; ALK-4; ALK2; FOP; Serine/threonine-protein kinase receptor R2; SKR1; TSRI; unnamed protein product
Gene Aliases: 6820432J04; ActR-IB; ACTRIB; ACVRLK4; ALK-4; ALK4; SKR2
UniProt ID: (Human) P36896, (Mouse) Q61271, (Rat) P80202
Entrez Gene ID: (Human) 91, (Mouse) 11479, (Rat) 29381
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
protein binding
ATP binding
activin receptor activity, type I
activin-activated receptor activity
growth factor binding
ubiquitin protein ligase binding
inhibin binding
SMAD binding
activin binding
I-SMAD binding
G1/S transition of mitotic cell cycle
regulation of transcription, DNA-templated
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
nervous system development
regulation of gene expression
peptidyl-threonine phosphorylation
negative regulation of ossification
negative regulation of cell growth
regulation of cell migration
activin receptor signaling pathway
positive regulation of activin receptor signaling pathway
nodal signaling pathway
negative regulation of cell differentiation
positive regulation of erythrocyte differentiation
protein autophosphorylation
regulation of multicellular organismal process
cellular response to growth factor stimulus
extrinsic apoptotic signaling pathway
positive regulation of trophoblast cell migration
in utero embryonic development
hair follicle development
cell surface receptor signaling pathway
mesoderm development
regulation of signal transduction
positive regulation of gene expression
negative regulation of gene expression
positive regulation of collagen biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
cardiac fibroblast cell development
protein phosphorylation
response to activity
development of primary female sexual characteristics
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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