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Invitrogen
Phospho-Cdc6 (Ser54) Recombinant Rabbit Monoclonal Antibody (0K9Y2)
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FIGURE: 1 / 1
Phospho-Cdc6 (Ser54) Antibody (MA5-38237) in WB
Western blot analysis of Phospho-Cdc6 (Ser54) in extracts of NIH/3T3 cells. Samples were incubated with Phospho-Cdc6 (Ser54) Monoclonal antibody (Product # MA5-38237) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. NIH/3T3 cells were treated by Paclitaxel (1 µM) at 37°C for 20 hours. NIH/3T3 cells were treated by Hydroxyurea (4 mM) at 37°... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-38237
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
0K9Y2
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: NIH/3T3
Immunogen sequence: PLSPR
Target Information
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC6-related protein; cell division control protein 6 homolog; cell division cycle 6 homolog; unnamed protein product
Gene Aliases: CDC18L; p62(cdc6)
UniProt ID: (Mouse) O89033
Entrez Gene ID: (Mouse) 23834
DNA replication initiation
regulation of mitotic metaphase/anaphase transition
positive regulation of cytokinesis
mitotic DNA replication checkpoint
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of fibroblast proliferation
cell division
positive regulation of chromosome segregation
cellular response to vasopressin
cellular response to angiotensin
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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