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Invitrogen
alpha Adducin Monoclonal Antibody (5D4H1)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-38440
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5D4H1
Immunogen
Purified recombinant fragment of human ADD1 (aa: 1-193) expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADD2; ADDB; adducin 1 (alpha); Adducin beta; Adducin-1; Adducin-alpha; Adducin-beta; Adducin1; Alpha adducin; alpha-adducin 1; beta Adducin; Beta-adducin; calmodulin-binding protein; erythrocyte adducin alpha subunit; unnamed protein product
Gene Aliases: ADDA
UniProt ID: (Human) P35611
Entrez Gene ID: (Human) 118
RNA binding
actin binding
protein binding
cytoskeletal adaptor activity
spectrin binding
protein homodimerization activity
cadherin binding
protein heterodimerization activity
protein dimerization activity
actin filament binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
cytoskeleton organization
actin cytoskeleton organization
regulation of actin filament polymerization
regulation of cellular component size
barbed-end actin filament capping
actin filament bundle assembly
positive regulation of developmental process
positive regulation of cellular component organization
cellular response to calcium ion
positive regulation of establishment of endothelial barrier
positive regulation of adherens junction organization
regulation of multicellular organismal development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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