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Invitrogen

SLUG Monoclonal Antibody (4B6D5)

1 Published Figure
1 Reference
View all (51) SLUG antibodies

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SLUG Monoclonal Antibody (4B6D5)

Product Details

MA5-38634

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunocytochemistry (ICC/IF)

1:200-1:1,000
-

Flow Cytometry (Flow)

1:200-1:400
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4B6D5

Immunogen

Purified recombinant fragment of human SNAI2 (aa: 100-200) expressed in E. Coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898546

Product Specific Information

This antibody has been tested in indirect ELISA.

Target Information

Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: MGC10182; neural crest transcription factor SLUG; protein snail homolog 2; slug (chicken homolog), zinc finger protein; snail family zinc finger 2; snail homolog 2; unnamed protein product; zinc-finger protein

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Gene Aliases: SLUG; SLUGH; SLUGH1; SNAIL2; WS2D

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UniProt ID: (Human) O43623

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Entrez Gene ID: (Human) 6591

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding protein binding sequence-specific DNA binding E-box binding sequence-specific double-stranded DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation epithelial to mesenchymal transition aortic valve morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation cell migration involved in endocardial cushion formation regulation of transcription, DNA-templated Notch signaling pathway sensory perception of sound negative regulation of keratinocyte proliferation negative regulation of vitamin D biosynthetic process neural crest cell development positive regulation of cell migration negative regulation of chondrocyte differentiation regulation of chemokine production negative regulation of cell adhesion mediated by integrin desmosome disassembly pigmentation negative regulation of DNA damage response, signal transduction by p53 class mediator regulation of osteoblast differentiation mesenchymal cell differentiation epithelium development negative regulation of vitamin D receptor signaling pathway cellular response to epidermal growth factor stimulus negative regulation of canonical Wnt signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of bicellular tight junction assembly negative regulation of anoikis negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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