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Invitrogen
CD3/CD19 (Blinatumomab Biosimilar) Recombinant Mouse Monoclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-41729
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ scFv, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Human CD19/CD3E
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.75 mg/mL
Amount
100 µg
Purification
Metal-chelate chromatography
Storage buffer
30mM histidine, pH 5.8, with 10% sucrose, 0.02% Tween 80
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
Target Information
CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lamda light chains. It appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation. It is expressed in all B cell precursor leukemias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-lymphocyte surface antigen B4; CD19 differentiation antigen; CD247; CD247 antigen, zeta subunit; CD3 antigen, delta subunit; CD3 delta; CD3 epsilon; CD3-epsilon; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3Z antigen, zeta polypeptide (TiT3 complex); CD3zeta chain; component of the TCR/CD3 complex; differentiation antigen CD19; FLJ18683; OKT3, delta chain; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell surface antigen Leu-12; T-cell surface antigen T3/Leu-4 epsilon chain; TCR zeta; TCR zeta chain; tissue factor-targeting CAR1 dimer; tissue factor-targeting CAR1 monomer; unnamed protein product
Gene Aliases: B4; CD3-DELTA; CD3-GAMMA; CD3-ZETA; CD3DELTA; CD3epsilon; CD3GAMMA; CD3H; CD3Q; CD3Z; CD3ZETA; CVID3; IMD17; IMD18; IMD19; IMD25; T3D; T3E; T3G; T3Z; TCRE; TCRZ
UniProt ID: (Human) P15391, (Human) P20963, (Human) P04234, (Human) P07766, (Human) P09693
Entrez Gene ID: (Human) 930, (Human) 919, (Human) 915, (Human) 916, (Human) 917
coreceptor activity
transmembrane signaling receptor activity
protein binding
protein binding, bridging
MHC class II receptor activity
identical protein binding
protein homodimerization activity
protein heterodimerization activity
protein tyrosine kinase binding
SH3 domain binding
protein kinase binding
receptor signaling complex scaffold activity
T cell receptor binding
B cell proliferation involved in immune response
immunoglobulin mediated immune response
B cell proliferation
antigen receptor-mediated signaling pathway
B cell receptor signaling pathway
regulation of B cell receptor signaling pathway
regulation of B cell activation
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of protein kinase B signaling
adaptive immune response
cell surface receptor signaling pathway
Fc-gamma receptor signaling pathway
gamma-delta T cell activation
alpha-beta T cell activation
T cell receptor signaling pathway
protein oligomerization
protein-containing complex assembly
positive thymic T cell selection
establishment or maintenance of cell polarity
protein transport
T cell activation
regulation of lymphocyte apoptotic process
positive regulation of cell-matrix adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
signal complex assembly
G-protein coupled receptor signaling pathway
regulation of signal transduction
positive regulation of gene expression
negative regulation of gene expression
dendrite development
cerebellum development
positive regulation of cell-cell adhesion mediated by integrin
positive regulation of T cell proliferation
regulation of apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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