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Invitrogen

CD51/CD61 (Tadocizumab Biosimilar) Recombinant Human Monoclonal Antibody

View all (15) CD51/CD61 antibodies

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Product Details

MA5-41731

Applications
Tested Dilution
Publications

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgG1, F(ab), kappa

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Immunogen

Human ITGA2B_ITGB3

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.15 mg/mL

Amount

100 µg

Purification

Protein L, Protein A/G

Storage buffer

PBS, pH 7.5

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2910874

Product Specific Information

Endotoxin level < 0.01EU/µg by LAL method

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.

This product is a Humanized mouse antibody.

Target Information

CD51 and CD61 molecules (alpha V and beta 3 integrins) form a complex. This complex binds vitronection at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. Reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: antigen CD61; antigen identified by monoclonal antibody L230; glycoprotein IIIa precursor; integrin alpha-5 beta-3; integrin alphaVbeta3; integrin beta 3; integrin beta chain, beta 3; integrin beta-3; integrin beta-3 subunit; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); plate glycoprotein IIIa (GPIIIa); platelet membrane glycoprotein IIIa; unnamed protein product; vitronectin alpha subunit precursor; vitronectin receptor subunit alpha

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Gene Aliases: BDPLT16; BDPLT2; BDPLT24; CD51; CD61; FMAIT1; GP3A; GPIIIa; GT; GT2; IDNDC; MSK8; VNRA; VTNR

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UniProt ID: (Human) P06756, (Human) P05106

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Entrez Gene ID: (Human) 3685, (Human) 3690

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Function(s)
opsonin binding fibronectin binding protease binding protein kinase C binding receptor binding integrin binding protein binding coreceptor activity fibroblast growth factor binding C-X3-C chemokine binding insulin-like growth factor I binding signaling receptor activity neuregulin binding transforming growth factor beta binding extracellular matrix binding extracellular matrix protein binding protein disulfide isomerase activity obsolete cell adhesion receptor activity platelet-derived growth factor receptor binding enzyme binding identical protein binding vascular endothelial growth factor receptor 2 binding cell adhesion molecule binding fibrinogen binding
Process(es)
angiogenesis positive regulation of endothelial cell proliferation positive regulation of leukocyte migration cell adhesion cell-matrix adhesion integrin-mediated signaling pathway embryo implantation blood coagulation regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell proliferation positive regulation of endothelial cell migration positive regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of fibroblast migration negative regulation of lipid storage negative regulation of low-density lipoprotein particle clearance response to activity smooth muscle cell migration positive regulation of smooth muscle cell migration cell migration platelet activation positive regulation of cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway cell-substrate adhesion negative regulation of lipid transport regulation of protein localization regulation of actin cytoskeleton organization cell adhesion mediated by integrin positive regulation of cell adhesion mediated by integrin cell-cell adhesion mediated by integrin positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading tube development wound healing, spreading of epidermal cells response to platelet-derived growth factor apolipoprotein A-I-mediated signaling pathway wound healing apoptotic cell clearance regulation of bone resorption positive regulation of angiogenesis positive regulation of bone resorption viral entry into host cell mesodermal cell differentiation positive regulation of smooth muscle cell proliferation negative regulation of lipoprotein metabolic process regulation of developmental process negative chemotaxis regulation of transport regulation of multicellular organismal process regulation of release of sequestered calcium ion into cytosol regulation of serotonin uptake angiogenesis involved in wound healing positive regulation of ERK1 and ERK2 cascade platelet aggregation cellular response to mechanical stimulus cellular response to xenobiotic stimulus positive regulation of glomerular mesangial cell proliferation maintenance of postsynaptic specialization structure regulation of postsynaptic neurotransmitter receptor internalization regulation of postsynaptic neurotransmitter receptor diffusion trapping positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway positive regulation of vascular endothelial growth factor signaling pathway cellular response to insulin-like growth factor stimulus negative regulation of endothelial cell apoptotic process positive regulation of T cell migration vasculogenesis formation of primary germ layer positive regulation of cytosolic calcium ion concentration tissue development endodermal cell differentiation positive regulation of cell adhesion regulation of phagocytosis positive regulation of small GTPase mediated signal transduction ERK1 and ERK2 cascade calcium ion transmembrane transport transforming growth factor beta production entry into host cell by a symbiont-containing vacuole extrinsic apoptotic signaling pathway in absence of ligand cell-cell adhesion positive regulation of intracellular signal transduction negative regulation of entry of bacterium into host cell negative regulation of extrinsic apoptotic signaling pathway
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