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Invitrogen

CD11a/CD18 (Rovelizumab Biosimilar) Recombinant Human Monoclonal Antibody

View all (4) CD11a/CD18 antibodies

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Product Details

MA5-41889

Applications
Tested Dilution
Publications

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgG4

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Immunogen

Human ITGAL/CD11a/ITGB2/CD18

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.86 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911032

Product Specific Information

Endotoxin level < 0.01EU/µg by LAL method

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.

This product is a Humanized mouse antibody.

Target Information

CD11/CD18 (LFA-1) are beta 2-type integrins. The leukocyte integrins are a family of heterodimeric receptors that mediate divalent cation-dependent cellular adhesion reactions. T cells use integrins in essentially all of their functions. Integrins become active following signalling through other membrane receptors, which cause both affinity alteration and an increase in integrin clustering. The monoclonal antibody 24 recognizes a structural feature and is strictly dependent upon the presence of Mg2+. The epitope is located within, or in close proximity to, the three conserved cation binding domains and therefore a measure of Mg2+ bound to the leukocyte integrins and thus reflects functionally active molecules. The epitope can be induced on polymorphonuclear leukocytes and on monocytes. Glu173 and Glu175 of the beta(2) I domain are identified as critical for antibody 24 binding. The monoclonal antibody 24 inhibits monocyte-dependent, antigen specific T cell proliferation and IL-2- activated natural killer cell assays. The antibody does not interfere with mitogen-stimulated T cell proliferation. Furthermore the monoclonal antibody 24 prevents deadhesion of receptor/ligand pairs, possible locking leukocyte integrins in an active conformation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide; CD11 antigen-like family member A; cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor); complement component 3 receptor 3 and 4 subunit; complement receptor C3 beta-subunit; human neutrophil antigen 5; integrin beta chain, beta 2; integrin gene promoter; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte adhesion protein beta-subunit precursor; leukocyte cell adhesion molecule CD18; leukocyte function-associated molecule 1 alpha chain; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; LFA-1 alpha; LFA-1A; lymphocyte function-associated antigen 1, alpha polypeptide; putative; unnamed protein product

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Gene Aliases: CD11A; CD18; EV6; HNA-5; LAD; LCAMB; LFA-1; LFA1A; MAC-1; MF17; MFI7

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UniProt ID: (Human) P20701, (Human) P05107

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Entrez Gene ID: (Human) 3683, (Human) 3689

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Function(s)
obsolete cell adhesion receptor activity protein binding ICAM-3 receptor activity signaling receptor activity macromolecular complex binding cell adhesion molecule binding beta-amyloid binding complement component C3b binding integrin binding protein kinase binding heat shock protein binding cargo receptor activity
Process(es)
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell inflammatory response cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules neuron cell-cell adhesion leukocyte cell-cell adhesion cell-matrix adhesion signal transduction integrin-mediated signaling pathway cell adhesion mediated by integrin cell-cell adhesion mediated by integrin memory T cell extravasation T cell activation receptor clustering cell-cell adhesion microglial cell activation leukocyte migration involved in inflammatory response receptor-mediated endocytosis phagocytosis phagocytosis, engulfment apoptotic process I-kappaB kinase/NF-kappaB signaling cell-cell signaling regulation of cell shape neutrophil chemotaxis receptor internalization positive regulation of superoxide anion generation heterotypic cell-cell adhesion endodermal cell differentiation positive regulation of neutrophil degranulation endothelial cell migration cellular extravasation positive regulation of nitric oxide biosynthetic process positive regulation of angiogenesis negative regulation of dopamine metabolic process anatomical structure formation involved in morphogenesis regulation of peptidyl-tyrosine phosphorylation leukocyte adhesion to vascular endothelial cell cellular response to low-density lipoprotein particle stimulus positive regulation of protein targeting to membrane beta-amyloid clearance positive regulation of leukocyte adhesion to vascular endothelial cell neutrophil migration
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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