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Invitrogen
KIR2DL1/2/3 (Lirilumab Biosimilar) Recombinant Human Monoclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-41973
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG4, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Human KIRD2 subgroup
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
Target Information
KIR2DL1 gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with autosomal dominant centronuclear myopathy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 18. KIR2DL2 and KIR2DL3 are genes belonging to the killer cell immunoglobulin-like receptor (KIR) family, located on chromosome 19q13.4. They encode inhibitory receptors expressed primarily on natural killer (NK) cells and a subset of T cells. The proteins produced by these genes play a key role in regulating the immune response through their interaction with human leukocyte antigen (HLA) class I molecules, specifically HLA-C alleles. KIR2DL2 recognizes a broad range of HLA-C alleles with a lysine at position 80 (C1 group), while KIR2DL3 has a higher affinity for the HLA-C1 group. Structurally, these receptors consist of two extracellular immunoglobulin-like domains, a transmembrane region, and a long cytoplasmic tail that contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Upon ligand binding, these receptors transmit inhibitory signals to prevent NK cell activation, thereby protecting healthy cells from immune destruction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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