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Invitrogen
Shiga toxin 1 (Pritoxaximab Biosimilar) Recombinant Human Monoclonal Antibody
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FIGURE: 1 / 1
Shiga toxin 1 (Pritoxaximab Biosimilar) Antibody (MA5-41995) in SDS-PAGE
SDS-PAGE analysis of the recombinant Escherichia coli shiga toxin type 1 B subunit protein expressed in CHO cells using a Shiga toxin 1 (Pritoxaximab Biosimilar) monoclonal antibody (Product # MA5-41995). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-41995
Product Specifications
Species Reactivity
Bacteria
Host/Isotype
Human
/ IgG1, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Escherichia coli shiga toxin type 1 B subunit
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
MA5-41995 is a chimeric antibody. The variable regions from one species have been grafted to the backbone of the other species.
Target Information
Shiga toxin 1 (Stx1) is produced by certain strains of Shigella dysenteriae and Escherichia coli, including strains that cause severe gastrointestinal diseases such as dysentery and hemorrhagic colitis. Structurally, Stx1 is an AB5 toxin, composed of one enzymatically active A subunit and five identical B subunits. The A subunit contains the N-glycosidase enzyme that inactivates the 28S ribosomal RNA, thereby halting protein synthesis and leading to cell death. The B subunits form a pentameric ring that binds to the glycolipid receptor Gb3 (globotriaosylceramide) on the surface of host cells, facilitating the entry of the A subunit into the cell. Functionally, Stx1 is highly cytotoxic and contributes to the pathogenicity of bacterial strains that produce it, leading to serious conditions such as hemolytic uremic syndrome (HUS) characterized by kidney failure, hemolytic anemia, and thrombocytopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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