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Invitrogen

cIAP1 Recombinant Rabbit Monoclonal Antibody (HL1045)

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Product Details

MA5-42354

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-
Product Specifications

Species Reactivity

Dog, Cat, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL1045

Immunogen

Recombinant protein encompassing a sequence within the center region of human cIAP1. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911495

Product Specific Information

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Information

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: apoptosis inhibitor 1; apoptosis inhibitor 2; baculoviral IAP repeat-containing 3; cellular inhibitor of apoptosis 1; IAP homolog B; inhibitor of apoptosis protein; inhibitor of apoptosis protein 2; NFR2-TRAF signalling complex protein; RIAP-2; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2; unnamed protein product

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Gene Aliases: API1; Api2; Birc3; C-IAP1; C330006D17Rik; cIAP1; cIAP2; Hiap-2; HIAP1; HIAP2; IAP-2; IAP1; IAP2; mcIAP1; MIAP1; MIAP2; MIHB; MIHC; rIAP1; RNF48

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UniProt ID: (Human) Q13490, (Mouse) Q62210

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Entrez Gene ID: (Dog) 479464, (Human) 329, (Rat) 60371, (Mouse) 11797

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Function(s)
transcription coactivator activity ubiquitin-protein transferase activity protein binding zinc ion binding transferase activity identical protein binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process ubiquitin binding macromolecular complex binding chaperone binding ubiquitin protein ligase activity FBXO family protein binding protease inhibitor
Process(es)
protein polyubiquitination response to hypoxia inflammatory response cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of protein ubiquitination tumor necrosis factor-mediated signaling pathway regulation of toll-like receptor signaling pathway NIK/NF-kappaB signaling regulation of RIG-I signaling pathway regulation of cell proliferation regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process regulation of innate immune response response to ethanol regulation of cell differentiation positive regulation of transcription, DNA-templated regulation of inflammatory response response to cAMP regulation of cell cycle regulation of necroptotic process negative regulation of necroptotic process necroptotic process regulation of nucleotide-binding oligomerization domain containing signaling pathway positive regulation of protein K63-linked ubiquitination positive regulation of protein K48-linked ubiquitination positive regulation of protein monoubiquitination response to bleomycin placenta development cellular response to tumor necrosis factor regulation of NIK/NF-kappaB signaling negative regulation of ripoptosome assembly involved in necroptotic process positive regulation of protein polyubiquitination regulation of reactive oxygen species metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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