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Invitrogen

ACVR2B Monoclonal Antibody (A5H7)

View all (21) ACVR2B antibodies

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ACVR2B Monoclonal Antibody (A5H7)

Product Details

MA5-42557

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat, Zebrafish

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

A5H7

Immunogen

Synthetic peptide within human ACVR2B aa 331-380.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Amount

200 µg

Purification

Protein G

Storage buffer

TBS, pH 7.4, with 50% glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911698

Product Specific Information

Positive Control: Hela cell lysates.

Subcellular Location: Cell membrane.

Target Information

ACVR2B is a type II member of the TGF-beta family of receptor ser/thr kinases and is involved in the activin and myostatin signaling pathway. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. To date, seven type I and five type II activin receptors have been cloned from mammals, including activin receptor IA, activin receptor IIA, activin receptor IB, and activin receptor IIB. In addition, two splice variants of activin receptor IIA and five splice variants of activin receptor IIB have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A receptor, type IIB; activin A receptor, type IIBa; activin receptor IIB; activin receptor type IIB; Activine receptor 2b (transmembrane serine kinase); ACTR-IIB; ActRIIB type II activin receptor B; MGC116908; probable match to ACTIVIN RECEPTOR TYPE IIB PRECURSOR (ACTR-IIB); serine/threonine receptor kinase

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Gene Aliases: 4930516B21Rik; ActR-IIB; actr2b; ACTRIIB; acvr2b; AI047905; HTX4; wu:fj97d11

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UniProt ID: (Human) Q13705, (Mouse) P27040, (Rat) P38445

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Entrez Gene ID: (Human) 93, (Mouse) 11481, (Rat) 25366, (Zebrafish) 30457

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Function(s)
protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding activin receptor activity, type II activin-activated receptor activity kinase activator activity growth factor binding activin binding inhibin binding transmembrane receptor protein kinase activity nucleotide binding kinase activity transferase activity metal ion binding serine/threonine protein kinase receptor
Process(es)
negative regulation of transcription from RNA polymerase II promoter lymphangiogenesis blood vessel remodeling regulation of transcription, DNA-templated cellular iron ion homeostasis signal transduction transmembrane receptor protein serine/threonine kinase signaling pathway pattern specification process anterior/posterior pattern specification negative regulation of ossification positive regulation of bone mineralization BMP signaling pathway developmental process activin receptor signaling pathway positive regulation of activin receptor signaling pathway positive regulation of osteoblast differentiation lymphatic endothelial cell differentiation artery development venous blood vessel development retina vasculature development in camera-type eye trophoblast cell migration cellular response to growth factor stimulus negative regulation of cold-induced thermogenesis negative regulation of adipose tissue development skeletal system development gastrulation with mouth forming second kidney development cell communication determination of left/right symmetry mesoderm development heart development response to glucose post-embryonic development regulation of signal transduction signaling insulin secretion lung development pancreas development organ growth odontogenesis of dentin-containing tooth embryonic foregut morphogenesis skeletal system morphogenesis palate development protein phosphorylation response to activity adrenal gland development neural crest cell migration phosphorylation hindbrain development cartilage development
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