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Invitrogen
MST1 (STK4) Recombinant Rabbit Monoclonal Antibody (001)
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Product Details
MA5-43143
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
001
Immunogen
Recombinant Human STK4/MST1 protein (2-487).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Specificity: Human STK4/MST1
Target Information
STK4 (MST1) is a serine/threonine kinase which may be involved in apoptosis. It is possible that this protein induces the chromatin condensation observed in this process. STK4 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.11.1; hippo homolog; kinase MST1; kinase responsive to stress 2; mammalian STE20-like protein kinase 1; mammalian sterile 20-like 1; serine/threonine-protein kinase Krs-2; STE20-like kinase MST1; TIIAC; unnamed protein product
Gene Aliases: KRS2; MST1; YSK3
UniProt ID: (Human) Q13043
Entrez Gene ID: (Human) 6789
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
identical protein binding
protein homodimerization activity
protein serine/threonine kinase activator activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
protein serine kinase activity
cell morphogenesis
positive regulation of protein phosphorylation
protein phosphorylation
protein import into nucleus
apoptotic process
signal transduction
anatomical structure morphogenesis
peptidyl-serine phosphorylation
positive regulation of peptidyl-serine phosphorylation
hippo signaling
positive regulation of hippo signaling
intracellular signal transduction
positive regulation of apoptotic process
regulation of MAPK cascade
protein autophosphorylation
protein stabilization
protein tetramerization
negative regulation of canonical Wnt signaling pathway
positive regulation of substrate-dependent cell migration, cell attachment to substrate
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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