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Invitrogen

IL-18 Monoclonal Antibody (C10)

View all (63) IL-18 antibodies

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IL-18 Monoclonal Antibody (C10)

Product Details

MA5-43740

Applications
Tested Dilution
Publications

Western Blot (WB)

0.01-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5-20 µg/mL
-
Product Specifications

Species Reactivity

Human, Pig, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

C10

Immunogen

Arg94-Asp193 (Accession Q14116), with N-terminal His Tag
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912672

Target Information

The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein can specifically interact with this cytokine, and thus negatively regulate its biological activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cytokine; iboctadekin; IFN-gamma-inducing factor; il 18; IL-1 gamma; IL-18; IL18; ILN; interferon gamma-inducing factor; interferon-gamma-inducing factor; Interleukin; interleukin 18 (interferon-gamma-inducing factor); interleukin-1 gamma; Interleukin18; MGC12320

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Gene Aliases: IGIF; IL-1 gamma; IL-18; IL-1g; IL1F4

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UniProt ID: (Pig) O19073, (Human) Q14116, (Rat) P97636

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Entrez Gene ID: (Pig) 397057, (Human) 3606, (Rat) 29197

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Function(s)
cytokine activity interleukin-18 receptor binding protein binding receptor agonist activity cytokine interleukin superfamily intercellular signal molecule
Process(es)
MAPK cascade angiogenesis inflammatory response cell proliferation positive regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors positive regulation of macrophage derived foam cell differentiation positive regulation of phosphatidylinositol 3-kinase signaling natural killer cell activation lipopolysaccharide-mediated signaling pathway activation of protein kinase B activity interferon-gamma production interleukin-6 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-17 production positive regulation of natural killer cell proliferation interleukin-18-mediated signaling pathway T-helper 1 cell cytokine production positive regulation of activated T cell proliferation neutrophil activation natural killer cell mediated cytotoxicity positive regulation of tyrosine phosphorylation of STAT protein cholesterol homeostasis positive regulation of T-helper 2 cell differentiation negative regulation of myoblast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle cell proliferation positive regulation of NF-kappaB transcription factor activity positive regulation of NK T cell proliferation positive regulation of protein kinase B signaling triglyceride homeostasis cellular response to organic cyclic compound positive regulation of cold-induced thermogenesis positive regulation of NIK/NF-kappaB signaling positive regulation of T-helper 1 cell cytokine production negative regulation of T-helper 1 type immune response immune response cell surface receptor signaling pathway cell-cell signaling cytokine-mediated signaling pathway regulation of cell adhesion sleep positive regulation of chemokine production positive regulation of interleukin-13 production positive regulation of tissue remodeling T-helper 1 type immune response type 2 immune response T-helper 1 cell differentiation positive regulation of inflammatory response defense response to Gram-positive bacterium establishment of skin barrier cellular response to lipopolysaccharide positive regulation of neuroinflammatory response osteoblast differentiation response to hypoxia positive regulation of cytokine production learning or memory positive regulation of gene expression positive regulation of smooth muscle cell migration lung development positive regulation of interleukin-1 beta production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of superoxide anion generation positive regulation of collagen biosynthetic process negative regulation of neutrophil apoptotic process positive regulation of apoptotic process positive regulation of vascular permeability response to peptide hormone positive regulation of neuron apoptotic process regulation of circadian sleep/wake cycle, non-REM sleep digestive tract morphogenesis negative regulation of peptidyl-tyrosine phosphorylation detection of mechanical stimulus involved in sensory perception of pain response to hyperoxia cellular response to hydrogen peroxide cellular response to mechanical stimulus cellular response to cAMP cellular response to interferon-gamma cellular response to tumor necrosis factor cellular response to parathyroid hormone stimulus cellular response to peptide hormone stimulus liver regeneration positive regulation of male germ cell proliferation positive regulation of hepatocyte proliferation positive regulation of blood vessel remodeling
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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