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Invitrogen
Cathelicidin Monoclonal Antibody (C1)
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Product Details
MA5-43917
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
C1
Immunogen
Gln31-Ser170 (Accession P49913), with N-terminal His Tag
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Cathelicidin is an epithelial-derived antimicrobial protein found in specific granules of polymorphonuclear leukocytes of bone marrow, testis and neutrophils. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 18 kDa cationic antimicrobial protein; CAMP; epididymis secretory sperm binding protein; hCAP-18; hCAP18
Gene Aliases: CAP-18; CAP18; CRAMP; FALL-39; FALL39; HSD26; LL37
UniProt ID: (Human) P49913
Entrez Gene ID: (Human) 820
response to yeast
innate immune response in mucosa
prostaglandin production involved in inflammatory response
chronic inflammatory response
positive regulation of antimicrobial humoral response
defense response
positive regulation of cell proliferation
response to glucose
leukotriene biosynthetic process
antibacterial humoral response
antifungal humoral response
cytolysis
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of insulin secretion involved in cellular response to glucose stimulus
modification of morphology or physiology of other organism
neutrophil activation
defense response to bacterium
negative regulation of apoptotic process
innate immune response
positive regulation of angiogenesis
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
antimicrobial humoral immune response mediated by antimicrobial peptide
cellular response to lipopolysaccharide
cellular response to peptidoglycan
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to exogenous dsRNA
positive regulation of monocyte chemotactic protein-1 production
positive regulation of macrophage inflammatory protein 1 alpha production
dentinogenesis
antibacterial innate immune response
cellular response to butyrate
amyloid fibril formation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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