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Invitrogen
Periostin Monoclonal Antibody (CL12087)
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FIGURE: 1 / 7
Periostin Antibody (MA5-44161) in ICC/IF
Immunofluorecent analysis of Periostin in U-138 cells using Periostin Monoclonal Antibody (CL12087) (Product # MA5-44161). Staining shows specific staining in vesicles in green. Microtubule- and nuclear probes are visualized in red and blue, respectively.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-44161
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
CL12087
Immunogen
Recombinant protein corresponding to Human POSTN
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: LTQPGDWTLF VPTNDAFKGM TSEE
Highest antigen sequence indentity to the following orthologs: Mouse - 96%, Rat - 92%.
Target Information
Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1(TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adhesion molecule; fasciclin I-like; Fasciclin-I like; MGC119510; MGC119511; OSF 2; osteoblast specific factor 2; osteoblast specific factor 2 (fasciclin I-like); periodontal ligament-specific periostin; periostin, osteoblast specific factor; RP11 412K4.1; RP11-412K4.1; unnamed protein product
Gene Aliases: OSF-2; OSF2; PDLPOSTN; PN
UniProt ID: (Human) Q15063
Entrez Gene ID: (Human) 10631
response to hypoxia
negative regulation of cell-matrix adhesion
regulation of systemic arterial blood pressure
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
response to mechanical stimulus
response to muscle activity
positive regulation of smooth muscle cell migration
extracellular matrix organization
response to estradiol
cellular response to fibroblast growth factor stimulus
cellular response to vitamin K
cellular response to tumor necrosis factor
cellular response to transforming growth factor beta stimulus
negative regulation of substrate adhesion-dependent cell spreading
neuron projection extension
bone regeneration
positive regulation of chemokine (C-X-C motif) ligand 2 production
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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