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Invitrogen
Kinesin 5B Recombinant Rabbit Monoclonal Antibody (JE64-16)
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FIGURE: 1 / 6
Kinesin 5B Antibody (MA5-44763) in IHC (P)
Immunohistochemistry analysis of KIF5B in paraffin-embedded human gallbladder tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with KIF5B Monoclonal antibody (Product # MA5-44763) using a dilution of 1:100 for 1 hour at room... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-44763
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE64-16
Immunogen
Synthetic peptide within human KIF5B aa 1-50.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: conventional kinesin heavy chain; epididymis secretory protein Li 61; KIF5B; uKHC; kinesin 1 (110-120kD); kinesin heavy chain; kinesin heavy chain member 5B, ubiquitous; U-KHC; ubiquitous kinesin heavy chain; UKHC; unnamed protein product
Gene Aliases: HEL-S-61; Khc; Khcs; KINH; KNS; KNS1; UKHC
UniProt ID: (Human) P33176, (Mouse) Q61768, (Rat) Q2PQA9
Entrez Gene ID: (Human) 3799, (Mouse) 16573, (Rat) 117550
mitochondrial transport
microtubule-based process
microtubule-based movement
cytoplasm organization
axon guidance
transport along microtubule
positive regulation of vesicle fusion
positive regulation of synaptic transmission, GABAergic
lysosome localization
stress granule disassembly
positive regulation of insulin secretion involved in cellular response to glucose stimulus
natural killer cell mediated cytotoxicity
regulation of membrane potential
positive regulation of potassium ion transport
vesicle transport along microtubule
mitochondrion transport along microtubule
synaptic vesicle transport
centrosome localization
cellular response to interferon-gamma
plus-end-directed vesicle transport along microtubule
positive regulation of intracellular protein transport
anterograde dendritic transport of neurotransmitter receptor complex
regulation of modification of synapse structure, modulating synaptic transmission
anterograde axonal protein transport
mitocytosis
positive regulation of protein localization to plasma membrane
positive regulation of voltage-gated sodium channel activity
retrograde neuronal dense core vesicle transport
hippocampus development
anterograde neuronal dense core vesicle transport
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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