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Invitrogen

CaV1.3 Monoclonal Antibody (S48), FITC

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CaV1.3 Monoclonal Antibody (S48), FITC

Product Details

MA5-45392

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-

Immunoprecipitation (IP)

Assay-dependent
-

Antibody Microarray (Ab Microarray)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

S48

Immunogen

Fusion protein amino acids 859-875 of rat Cav1.3
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

9.1mM sodium bicarbonate/PBS, pH 7.4, with 640.91mM DMSO, 136.36mM ethanolamine

Contains

no preservative

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931846

Product Specific Information

1 µg/mL of MA5-45392 was sufficient for detection of Cav1.3 in 10 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.|Detects approximately 250kDa. No cross-reactivity against Cav1.2.

Target Information

CACNA1D is also known as PASNA, SANDD or Cav1. 3. Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha 1 E; brain class D; CACNA 1D; calcium channel alpha-1 subunit; calcium channel, L type, alpha-1 polypeptide; calcium channel, neuroendocrine/brain-type, alpha 1 subunit; calcium channel, voltage-dependent, L type, alpha 1D subunit; CaV1.3alpha1; ion channel; RBD; unnamed protein product; variant CaCh3 (delta IVS3 delta IVS4); variant CaCh3 (delta IVS3 delta part IVS4); variant CaCh3b (delta part IVS4); voltage-dependent calcium channel subunit alpha1D; voltage-gated calcium channel alpha 1 subunit; voltage-gated calcium channel alpha subunit Cav1.3; voltage-gated calcium channel pore forming subunit CaV1.3alpha1 IVS3-IVS4 extracellular linker; voltage-gated calcium channel subunit alpha Cav1.3

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Gene Aliases: 8430418G19Rik; CACH3; CACN4; CACNL1A2; Cav1.3; Cchl1a; CCHL1A2; D-LTCC; PASNA; SANDD

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UniProt ID: (Human) Q01668, (Mouse) Q99246

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Entrez Gene ID: (Human) 776, (Rat) 29716, (Mouse) 12289

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Function(s)
ion channel activity voltage-gated calcium channel activity calcium channel activity protein binding cytoskeletal protein binding high voltage-gated calcium channel activity ankyrin binding alpha-actinin binding voltage-gated calcium channel activity involved in cardiac muscle cell action potential voltage-gated calcium channel activity involved SA node cell action potential voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels PDZ domain binding voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
Process(es)
ion transport calcium ion transport cell communication adenylate cyclase-modulating G-protein coupled receptor signaling pathway heart development sensory perception of sound memory regulation of metal ion transport calcium-mediated signaling optic nerve development signaling metal ion transport response to estradiol positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of adenylate cyclase activity neurological system process regulation of calcium ion transport positive regulation of calcium ion transport transmembrane transport regulation of atrial cardiac muscle cell membrane repolarization calcium ion import calcium ion transmembrane transport cardiac muscle cell action potential involved in contraction membrane depolarization during cardiac muscle cell action potential membrane depolarization during SA node cell action potential regulation of heart rate by cardiac conduction calcium ion import across plasma membrane regulation of presynaptic cytosolic calcium ion concentration regulation of potassium ion transmembrane transport regulation of intracellular signal transduction positive regulation of secretion by cell regulation of cation transmembrane transport positive regulation of membrane depolarization cellular response to beta-amyloid positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel muscle contraction positive regulation of transport cardiac conduction positive regulation of presynaptic cytosolic calcium concentration induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
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