Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

Phospho-ErbB2 (HER-2) (Tyr1248) Recombinant Rabbit Monoclonal Antibody (HL1466)

Advanced Verification
View all (308) Her-2 (ErbB2) antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Phospho-ErbB2 (HER-2) (Tyr1248) Recombinant Rabbit Monoclonal Antibody (HL1466)

Product Details

MA5-46898

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:200
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL1466

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human HER2 (phospho Tyr1248). The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2937970

Product Specific Information

Store as concentrated solution.

Centrifuge briefly prior to opening vial.

Target Information

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: approximately 68 kDa secreted autoinhibitor glycoprotein; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); c-erb B2/neu protein; C-erbB-2; CD antigen CD340; epidermal growth factor receptor-related protein; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; HER2 receptor; HER2/neu receptor; herstatin; human epidermal growth factor receptor 2; metas; metastatic lymph node gene 19 protein; neu oncogene; p185; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; p185 precursor; neu/erbB-2; p185erbB2; p185neu; phospho ErbB2; proto-oncogene c-ErbB-2; proto-oncogene NEU; receptor tyrosine-protein kinase erbB-2-like; tyrosine kinase-type cell surface receptor HER2; unnamed protein product; v-erb-b2 avian erythroblastic leukemia viral oncogene 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

View more View less

Gene Aliases: c-ERB-2; c-ERB2; CD340; HER-2; HER-2/neu; HER2; HER2/neu; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2

View more View less

UniProt ID: (Human) P04626

View more View less

Entrez Gene ID: (Human) 2064, (Rat) 24337

View more View less

Function(s)
RNA polymerase I core binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity receptor binding protein binding ATP binding coreceptor activity growth factor binding receptor tyrosine kinase binding identical protein binding ErbB-3 class receptor binding protein heterodimerization activity ubiquitin protein ligase binding macromolecular complex binding Hsp90 protein binding
Process(es)
liver development signal transduction cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway nervous system development peripheral nervous system development heart development skeletal muscle tissue development neuromuscular junction development female pregnancy motor neuron axon guidance cell proliferation positive regulation of cell proliferation response to xenobiotic stimulus glial cell differentiation positive regulation of gene expression Schwann cell development response to muscle activity peptidyl-tyrosine phosphorylation neuron differentiation positive regulation of cell growth axon regeneration response to progesterone regulation of microtubule-based process negative regulation of immature T cell proliferation in thymus response to vitamin D multicellular organismal response to stress positive regulation of Rho protein signal transduction intracellular signal transduction ERBB signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-EGFR signaling pathway ERBB2-ERBB4 signaling pathway wound healing regulation of cell proliferation myelination negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade protein kinase B signaling tongue development estrous cycle regulation of cell differentiation positive regulation of translation positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter positive regulation of JNK cascade positive regulation of Ras protein signal transduction protein autophosphorylation sympathetic nervous system development animal organ development response to axon injury oligodendrocyte differentiation positive regulation of epithelial cell proliferation positive regulation of small GTPase mediated signal transduction positive regulation of protein kinase B signaling mammary gland involution regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus semaphorin-plexin signaling pathway response to dexamethasone positive regulation of protein targeting to membrane neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of membrane permeability positive regulation of neural precursor cell proliferation protein phosphorylation enzyme linked receptor protein signaling pathway ERBB2 signaling pathway regulation of angiogenesis
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support