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Invitrogen
SMARCA2 Recombinant Rabbit Monoclonal Antibody (HL1114)
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FIGURE: 1 / 5
SMARCA2 Antibody (MA5-46932) in ICC/IF
Immunofluorescent analysis of SMARCA2 in HeLa cells. Cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: SMARCA2 stained by SMARCA2 monoclonal antibody (Product # MA5-46932) diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody [GT114] diluted at 1:1,000.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-46932
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL1114
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human SMARCA2. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Target Information
SMARCA2 encodes a protein that is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent helicase SMARCA2; BAF190B; brahma homolog; BRG1-associated factor 190B; FLJ36757; global transcription activator homologous sequence; MGC74511; N-terminal region of the protein; probable global transcription activator SNF2L2; protein brahma homolog; putative global transcription activator SNF2L2; SMARCA2; helicase; chromatin remodelling factor; SNF2-alpha; SNF2/SWI2-like protein 2; subunit of the SWI/SNF chromatin remodeling complex; sucrose nonfermenting 2-like protein 2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2; unnamed protein product
Gene Aliases: 2610209L14Rik; BAF190; BIS; brahma; BRM; hBRM; hSNF2a; NCBRS; SAMRCA2; SNF2; SNF2alpha; SNF2L2; SNF2LA; Sth1p; SWI2
UniProt ID: (Human) P51531, (Mouse) Q6DIC0
Entrez Gene ID: (Human) 6595, (Mouse) 67155, (Rat) 361745
chromatin organization
nucleosome assembly
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of mitotic metaphase/anaphase transition
negative regulation of cell growth
heterochromatin assembly
aortic smooth muscle cell differentiation
positive regulation of T cell differentiation
negative regulation of cell differentiation
positive regulation of cell differentiation
positive regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
hematopoietic stem cell homeostasis
regulation of G0 to G1 transition
positive regulation of stem cell population maintenance
regulation of G1/S transition of mitotic cell cycle
positive regulation of double-strand break repair
regulation of nucleotide-excision repair
negative regulation of transcription from RNA polymerase II promoter
spermatid development
nucleosome organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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