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Invitrogen

PI3K p85 alpha Recombinant Rabbit Monoclonal Antibody (HL1414)

View all (35) PI3K p85 alpha antibodies

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Product Details

MA5-47035

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL1414

Immunogen

Recombinant protein encompassing a sequence within the center region of human PI3 kinase p85 alpha. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2938107

Product Specific Information

Store as concentrated solution.

Centrifuge briefly prior to opening vial.

Target Information

Phosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1. Mutations in the gene can result in Agammaglobulinemia 7, SHORT syndrome, or Immunodeficiency 36.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: growth factor receptor bound 1; p55-GAMMA; p55PIK; p85-alpha; GRB1; phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit gamma; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase-associated p-85 alpha; phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); PI3 kinase-associated p85; PI3-kinase p85-subunit alpha; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; PI3K regulatory subunit gamma; PI3K-p46; polypeptide 1 p85 alpha; ptdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory subunit p85-al; RP4-533D7.2; unnamed protein product

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Gene Aliases: AGM7; GRB1; IMD36; p50alpha; p55alpha; p85; p85-ALPHA; p85alpha; PI3K

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UniProt ID: (Human) P27986, (Mouse) P26450

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Entrez Gene ID: (Human) 5295, (Mouse) 18708

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Function(s)
phosphotyrosine binding transmembrane receptor protein tyrosine kinase adaptor activity insulin receptor binding insulin-like growth factor receptor binding neurotrophin TRKA receptor binding protein binding kinase regulator activity kinase activator activity protein phosphatase binding phosphatidylinositol 3-kinase regulator activity phosphatidylinositol 3-kinase regulatory subunit binding ErbB-3 class receptor binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding 1-phosphatidylinositol-3-kinase regulator activity protein heterodimerization activity phosphatidylinositol kinase activity enzyme-substrate adaptor activity phosphatidylinositol 3-kinase activator activity receptor binding platelet-derived growth factor receptor binding calmodulin binding 1-phosphatidylinositol-3-kinase activity protein kinase binding protein domain specific binding estrogen receptor binding receptor tyrosine kinase binding ubiquitin protein ligase binding ATPase binding phosphoprotein binding
Process(es)
cellular glucose homeostasis positive regulation of protein phosphorylation negative regulation of cell-matrix adhesion glucose metabolic process protein phosphorylation protein import into nucleus negative regulation of cell adhesion signal transduction insulin receptor signaling pathway extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of heart rate positive regulation of lamellipodium assembly positive regulation of gene expression negative regulation of muscle cell apoptotic process cytokine-mediated signaling pathway negative regulation of cell-cell adhesion B cell differentiation positive regulation of cell migration positive regulation of tumor necrosis factor production response to insulin cellular response to insulin stimulus positive regulation of RNA splicing regulation of toll-like receptor 4 signaling pathway cellular response to UV response to endoplasmic reticulum stress interleukin-18-mediated signaling pathway phosphatidylinositol-3-phosphate biosynthetic process natural killer cell mediated cytotoxicity positive regulation of protein import into nucleus negative regulation of apoptotic process protein kinase B signaling positive regulation of cellular component biogenesis positive regulation of myoblast differentiation negative regulation of osteoclast differentiation negative regulation of blood pressure negative regulation of proteolysis positive regulation of transcription from RNA polymerase II promoter phosphatidylinositol metabolic process phosphatidylinositol phosphorylation insulin-like growth factor receptor signaling pathway positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation protein stabilization positive regulation of cellular component organization negative regulation of multicellular organismal process response to glucocorticoid positive regulation of filopodium assembly regulation of stress fiber assembly negative regulation of stress fiber assembly response to cAMP positive regulation of synapse assembly growth hormone receptor signaling pathway T follicular helper cell differentiation positive regulation of focal adhesion disassembly positive regulation of endoplasmic reticulum unfolded protein response regulation of protein localization to plasma membrane protein polyubiquitination immune response T cell differentiation substrate adhesion-dependent cell spreading positive regulation of glucose import positive regulation of protein localization to plasma membrane
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