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Invitrogen
MUC4 Recombinant Rabbit Monoclonal Antibody (HL1486)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-47062
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL1486
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Mucin 4. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Target Information
Nearly all mucosal surfaces are protected by mucin transmembrane glycoproteins, from bronchioles to corneas to reproductive tracts. Mucin 4 (MUC4) is membrane-bound and is important in protecting and lubricating. MUC4 expression is erroneous in many carcinomas and sarcomas, including fibromyoxoid sarcoma and pancreatic adenocarcinoma. Immunohistochemical staining for MUC4 has been discussed as a potential biomarker for detection of these cancers. MUC4 seems to be most predominantly affected in Asian diseases - Taiwanese infertility and endometriosis, as well as gallstone formation in Chinese men, are connected to MUC4, where similar diseases in other populations do not share these MUC4 mutations. Because MUC4 is so important in mucosal surface protection, it is not surprising that it has been implicated as failing in many metastatic cancer invasions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ascites sialoglycoprotein; ASGP1; large membrane-bound mucin; MUC4; MUC4; ascites sialoglycoprotein-2; ASGP-2; mucin 4, ASGP; mucin 4, tracheobronchial; Mucin4; pancreatic adenocarcinoma mucin; testis mucin; tracheobronchial mucin; unnamed protein product
Gene Aliases: 4933405I11Rik; ASGP; HSA276359; MUC-4
UniProt ID: (Human) Q99102, (Mouse) Q8JZM8
Entrez Gene ID: (Human) 4585, (Mouse) 140474
cell-matrix adhesion
maintenance of gastrointestinal epithelium
negative regulation of cell-matrix adhesion
hematopoietic progenitor cell differentiation
negative regulation of T cell mediated cytotoxicity directed against tumor cell target
regulation of receptor activity
negative regulation of cell-cell adhesion
negative regulation of apoptotic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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