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          • Primary Antibodies ›
          • beta Catenin Antibodies

          Invitrogen

          beta Catenin Recombinant Rabbit Monoclonal Antibody (HL1753)

          View all (226) beta Catenin antibodies

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          Cite beta Catenin Recombinant Rabbit Monoclonal Antibody (HL1753)

          Additional Information:
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          • Antibody Testing Data (14)
          beta Catenin Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          beta Catenin Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 14

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          beta Catenin Antibody (MA5-47169) in ICC/IF

          Immunofluorescent analysis of beta Catenin in A431 cells. Cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: beta Catenin stained by beta Catenin monoclonal antibody (Product # MA5-47169) diluted at 1:500. Blue: Fluoroshield with DAPI. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
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          beta Catenin Antibody in Immunocytochemistry (ICC/IF)
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          beta Catenin Antibody in Western Blot (WB)
          beta Catenin Antibody in Western Blot (WB)
          beta Catenin Antibody in Western Blot (WB)
          beta Catenin Antibody in Western Blot (WB)

          Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

          Product Details

          MA5-47169

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:3,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          2 µg/mL
          -

          Immunocytochemistry (ICC/IF)

          Assay-dependent
          -
          Product Specifications

          Species Reactivity

          Dog, Cat, Human, Mouse

          Host/Isotype

          Rabbit / IgG

          Expression System

          HEK293 cells

          Class

          Recombinant Monoclonal

          Type

          Antibody

          Clone

          HL1753

          Immunogen

          Recombinant protein of human beta Catenin

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Protein A

          Storage buffer

          PBS

          Contains

          no preservative

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2938241

          Product Specific Information

          Store as concentrated solution.

          Centrifuge briefly prior to opening vial.

          Target Information

          Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. The influence on cell proliferation is the molecular basis for the role of beta-catenin in tumorgenesis, specifically, solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Bioinformatics

          Protein Aliases: Bcatenin; beta 1 88kDa; beta-catenin; Betacatenin; C20orf33; Cadherin associated protein; catenin; catenin (cadherin associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin b 1; Catenin b1; Catenin beta1; Catenin β 1; Catenin β1; CTNB1; dJ633O20.1; DKFZp686D02253; FLJ25606; FLJ37923; NAP; NYD-SP19; OTTHUMP00000209289; P14L; PP8304; RP5-1118M15.1; unnamed protein product; β catenin; βcatenin

          View more View less

          Gene Aliases: armadillo; Bfc; Catnb; CTNNB; EVR7; Mesc; MRD19; NEDSDV

          View more View less

          UniProt ID: (Dog) B6V8E6, (Human) P35222, (Mouse) Q02248

          View more View less

          Entrez Gene ID: (Dog) 477032, (Human) 1499, (Mouse) 12387

          View more View less

          Function(s)
          RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding beta-catenin binding protein C-terminus binding protein kinase binding estrogen receptor binding ion channel binding I-SMAD binding repressing transcription factor binding disordered domain specific binding transcription cofactor binding transcription corepressor binding receptor binding ligand-dependent nuclear receptor binding enzyme binding kinase binding phosphatase binding protein phosphatase binding ubiquitin protein ligase binding alpha-catenin binding cadherin binding SMAD binding RNA polymerase II sequence-specific DNA binding transcription factor binding DNA-binding transcription factor binding histone methyltransferase binding nucleic acid binding ionotropic glutamate receptor binding macromolecular complex binding nitric-oxide synthase binding delta-catenin binding molecular function activator activity
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter protein polyubiquitination embryonic axis specification cell morphogenesis involved in differentiation patterning of blood vessels branching involved in ureteric bud morphogenesis in utero embryonic development gastrulation with mouth forming second cell fate specification endodermal cell fate commitment neuron migration neural plate development positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation lens morphogenesis in camera-type eye regulation of secondary heart field cardioblast proliferation metanephros morphogenesis negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis cell adhesion cell-matrix adhesion chemical synaptic transmission ectoderm development glial cell fate determination negative regulation of cell proliferation anterior/posterior axis specification dorsal/ventral axis specification proximal/distal pattern formation positive regulation of heparan sulfate proteoglycan biosynthetic process negative regulation of angiogenesis layer formation in cerebral cortex central nervous system vasculogenesis osteoclast differentiation male genitalia development hindbrain development regulation of centriole-centriole cohesion pancreas development hair follicle morphogenesis regulation of myelination positive regulation of telomere maintenance via telomerase negative regulation of chondrocyte differentiation response to estradiol T cell differentiation in thymus negative regulation of protein sumoylation adherens junction assembly protein localization to cell surface embryonic heart tube development genitalia morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic skeletal limb joint morphogenesis astrocyte-dopaminergic neuron signaling regulation of T cell proliferation odontogenesis of dentin-containing tooth response to drug embryonic digit morphogenesis positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of MAPK cascade positive regulation of neuron apoptotic process canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition bone resorption positive regulation of endothelial cell differentiation positive regulation of osteoblast differentiation negative regulation of osteoclast differentiation positive regulation of fibroblast growth factor receptor signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of mitotic cell cycle, embryonic chromatin-mediated maintenance of transcription cell maturation synaptic vesicle transport thymus development oocyte development embryonic foregut morphogenesis positive regulation of skeletal muscle tissue development regulation of smooth muscle cell proliferation negative regulation of oligodendrocyte differentiation synapse organization positive regulation of sequence-specific DNA binding transcription factor activity smooth muscle cell differentiation regulation of timing of anagen positive regulation of telomerase activity oviduct development canonical Wnt signaling pathway trachea formation epithelial tube branching involved in lung morphogenesis lung cell differentiation lung-associated mesenchyme development lung induction epithelial cell differentiation involved in prostate gland development positive regulation of epithelial cell proliferation involved in prostate gland development hair follicle placode formation mesenchymal cell proliferation involved in lung development endothelial tube morphogenesis fungiform papilla formation canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation sympathetic ganglion development cranial ganglion development regulation of centromeric sister chromatid cohesion bicellular tight junction assembly cellular response to growth factor stimulus cellular response to indole-3-methanol renal vesicle formation renal inner medulla development renal outer medulla development nephron tubule formation regulation of nephron tubule epithelial cell differentiation regulation of calcium ion import synaptic vesicle clustering cell-cell adhesion negative regulation of oxidative stress-induced neuron death positive regulation of chromatin-mediated maintenance of transcription regulation of euchromatin binding positive regulation of core promoter binding cranial skeletal system development midbrain dopaminergic neuron differentiation neuron projection extension embryonic brain development dorsal root ganglion development regulation of protein localization to cell surface positive regulation of determination of dorsal identity positive regulation of DNA-templated transcription, initiation negative regulation of apoptotic signaling pathway osteoblast differentiation epithelial to mesenchymal transition outflow tract morphogenesis epidermal growth factor receptor signaling pathway positive regulation of cell proliferation response to xenobiotic stimulus negative regulation of gene expression regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition stem cell population maintenance hypothalamus development neuron differentiation midbrain development regulation of protein ubiquitination positive regulation of transcription elongation from RNA polymerase II promoter positive regulation of homotypic cell-cell adhesion hair cell differentiation detection of muscle stretch negative regulation of apoptotic process cell-cell adhesion mediated by cadherin positive regulation of cell differentiation regulation of angiogenesis positive regulation of angiogenesis regulation of fibroblast proliferation embryonic organ development regulation of neurogenesis negative regulation of neurogenesis detection of mechanical stimulus regulation of synapse assembly mesenchymal to epithelial transition long term synaptic depression mesenchymal stem cell differentiation negative regulation of canonical Wnt signaling pathway positive regulation of odontoblast differentiation negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway positive regulation of blood vessel branching positive regulation of neural precursor cell proliferation cell morphogenesis skeletal system development angiogenesis vasculogenesis endoderm formation cell fate determination kidney development tissue homeostasis vasculature development ventricular compact myocardium morphogenesis regulation of transcription from RNA polymerase II promoter heart development protein localization cell proliferation dorsal/ventral pattern formation gene expression regulation of gene expression positive regulation of gene expression Schwann cell proliferation morphogenesis of embryonic epithelium dendrite development hair cycle process hemopoiesis cell differentiation T cell differentiation lung development regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation forebrain development response to cytokine adherens junction organization regulation of cell proliferation regulation of apoptotic process negative regulation of neuron apoptotic process skin development response to estrogen cell-cell junction organization regulation of cell differentiation negative regulation of cell differentiation regulation of osteoblast differentiation regulation of osteoclast differentiation animal organ development cardiac muscle cell proliferation limb development trachea morphogenesis mesenchyme development establishment of blood-brain barrier cardiac vascular smooth muscle cell differentiation coronary artery morphogenesis epicardium-derived cardiac vascular smooth muscle cell differentiation positive regulation of branching involved in lung morphogenesis cellular response to mechanical stimulus mesenchyme morphogenesis cellular response to insulin-like growth factor stimulus establishment of blood-retinal barrier
          It has to be done as per old AB suggested Products section.

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