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Invitrogen

FCGR2B Recombinant Rabbit Monoclonal Antibody (HL1948)

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View all (34) CD32b (FCGR2B) antibodies

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FCGR2B Recombinant Rabbit Monoclonal Antibody (HL1948)

Product Details

MA5-47232

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL1948

Immunogen

Recombinant protein encompassing a sequence within the C-terminus region of human CD32B. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Amount

200 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2938304

Product Specific Information

Store as concentrated solution.

Centrifuge briefly prior to opening vial.

Target Information

This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD32 receptor 2; CD32 receptor 2a; CD32 receptor 2b; CD32A; CDw32; Fc fragment of IgG receptor IIb; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor; Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc gamma receptor IIb; Fc gamma RIIb; Fc receptor, IgG, low affinity IIb; FC-gamma RII; fc-gamma RII-a; fc-gamma RII-b; fc-gamma-RIIa; fc-gamma-RIIb; FcGR; FCGR2A1; FCGR2B; FcgRIIB isoform 1; fcRII-a; fcRII-b; FGFR2B; IgG Fc fragment receptor; IgG Fc fragment receptor precursor; IgG Fc receptor beta-Fc-gamma-RII; igG Fc receptor II beta; igG Fc receptor II-b; low affinity immunoglobulin gamma Fc region receptor II-b

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Gene Aliases: CD32; CD32B; FCG2; FcgammaRIIB2; FCGR2; FCRII; IGFR2

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UniProt ID: (Human) P31994, (Rat) Q63203

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Entrez Gene ID: (Human) 2213, (Rat) 289211

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Function(s)
beta-amyloid binding protein binding IgG receptor activity low-affinity IgG receptor activity IgG binding macromolecular complex binding immunoglobulin binding
Process(es)
antibody-dependent cellular cytotoxicity immune effector process immune complex clearance regulation of immune system process receptor-mediated endocytosis phagocytosis cell surface receptor signaling pathway dendrite development cerebellum development response to estradiol endocytic recycling positive regulation of tumor necrosis factor production negative regulation of neutrophil apoptotic process Fc-gamma receptor signaling pathway positive regulation of JNK cascade regulation of long-term neuronal synaptic plasticity positive regulation of phagocytosis negative regulation of B cell receptor signaling pathway cellular response to lipopolysaccharide Fc receptor-mediated immune complex endocytosis regulation of dendritic spine maintenance regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway cellular response to beta-amyloid positive regulation of response to endoplasmic reticulum stress negative regulation of type I hypersensitivity negative regulation of antibody-dependent cellular cytotoxicity negative regulation of cytokine production follicular dendritic cell activation mature B cell differentiation involved in immune response follicular B cell differentiation immune complex clearance by monocytes and macrophages negative regulation of dendritic cell antigen processing and presentation regulation of B cell antigen processing and presentation negative regulation of immunoglobulin production regulation of adaptive immune response negative regulation of acute inflammatory response to antigenic stimulus positive regulation of humoral immune response negative regulation of humoral immune response mediated by circulating immunoglobulin defense response inflammatory response response to bacterium immunoglobulin mediated immune response antigen processing and presentation of exogenous peptide antigen via MHC class II negative regulation of B cell proliferation negative regulation of interleukin-10 production negative regulation of macrophage activation negative regulation of cytotoxic T cell degranulation regulation of innate immune response negative regulation of phagocytosis negative regulation of immune response negative regulation of B cell activation regulation of immune complex clearance by monocytes and macrophages negative regulation of neutrophil activation negative regulation of dendritic cell differentiation
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