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Invitrogen
Ubiquilin 2 Monoclonal Antibody (6H9)
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FIGURE: 1 / 2
Ubiquilin 2 Antibody (MA5-47367) in ICC/IF
Immunofluorescent analysis of Ubiquilin 2 in NIH-3T3 cell culture. Samples were stained with Ubiquilin 2 monoclonal antibody (Product # MA5-47466) using a dilution of 1:1,000 (green). Costained with chicken pAb to lamin A/C (Product # PA5-143574)dilution 1:5,000 in red. The blue is DAPI staining of nuclear DNA. The cells were treated with 50 µM of chloroquine, an inhibitor of autophagy, for 16 hours prior t... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-47367
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
6H9
Immunogen
Human ubiquilin 2 expressed in and purified from E. coli
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
500 µg
Purification
Protein A/G
Storage buffer
PBS with 50% glycerol
Contains
5mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytosolic protein; HRIHFB2157; Nedd4 binding protein 4; protein linking IAP with cytoskeleton 2; ubiquitin-like product Chap1/Dsk2; ubiquitin-like type II; Ubiquitin-related protein; unnamed protein product
Gene Aliases: ALS15; CHAP1; DSK2; HRIHFB2157; N4BP4; Plic-2; PLIC2; RGD1563566
UniProt ID: (Human) Q9UHD9, (Mouse) Q9QZM0
Entrez Gene ID: (Human) 29978, (Mouse) 54609, (Rat) 317396
autophagosome assembly
ubiquitin-dependent protein catabolic process
regulation of macroautophagy
ERAD pathway
negative regulation of clathrin-mediated endocytosis
negative regulation of G-protein coupled receptor internalization
positive regulation of ERAD pathway
regulation of autophagosome assembly
negative regulation of transport
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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