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Invitrogen

CDC42 Monoclonal Antibody (M430)

View all (21) CDC42 antibodies

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Product Details

MA5-47706

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunocytochemistry (ICC/IF)

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgM

Class

Monoclonal

Type

Antibody

Clone

M430

Immunogen

Clone (M430) was generated from a rat recombinant Cdc42 protein. This sequence is highly conserved in human and mouse Cdc42.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

50 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA, 50% glycerol

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2942687

Product Specific Information

The antibody detects a 21 kDa* protein in human Jurkat cells, rat A7r5 cells, and mouse brain. The antibody also detects recombinant full length rat Cdc42 fusion protein, but does not recognize a full length human RhoA GST fusion protein.

Target Information

Rac1 is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for the Rac1 gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cdc42; CDC42Mm; cell division cycle 42 (GTP binding protein); cell division cycle 42 homolog; dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)); G25K GTP-binding protein; growth-regulating protein; GTP binding protein, 25kDa; GTP-binding protein; GTP-binding protein G25K; RP1-224A6.5; small GTP binding protein; small GTP binding protein CDC42; small GTP binding protein; GTPase; unnamed protein product

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Gene Aliases: CDC42Hs; G25K; TKS

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UniProt ID: (Human) P60953, (Mouse) P60766, (Rat) Q8CFN2

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Entrez Gene ID: (Human) 998, (Mouse) 12540, (Rat) 64465

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Function(s)
GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding protein kinase binding GTP-dependent protein binding thioesterase binding GBD domain binding apolipoprotein A-I receptor binding identical protein binding ubiquitin protein ligase activity mitogen-activated protein kinase kinase kinase binding
Process(es)
heart process cardiac neural crest cell migration involved in outflow tract morphogenesis endocytosis phagocytosis, engulfment actin filament organization Golgi organization establishment or maintenance of cell polarity signal transduction integrin-mediated signaling pathway small GTPase mediated signal transduction anatomical structure morphogenesis regulation of lamellipodium assembly positive regulation of lamellipodium assembly substantia nigra development establishment of cell polarity actin cytoskeleton organization macrophage differentiation positive regulation of cell growth positive regulation of cell migration positive regulation of pseudopodium assembly negative regulation of protein complex assembly positive regulation of cytokinesis regulation of actin cytoskeleton organization cell junction assembly embryonic heart tube development neuropilin signaling pathway modulation by host of viral process establishment of epithelial cell apical/basal polarity positive regulation of pinocytosis positive regulation of cellular component organization regulation of filopodium assembly positive regulation of filopodium assembly regulation of stress fiber assembly positive regulation of stress fiber assembly establishment of Golgi localization regulation of attachment of spindle microtubules to kinetochore Wnt signaling pathway, planar cell polarity pathway positive regulation of epithelial cell proliferation involved in lung morphogenesis dendritic spine morphogenesis organelle transport along microtubule endothelin receptor signaling pathway regulation of postsynapse organization positive regulation of substrate adhesion-dependent cell spreading sprouting angiogenesis cardiac conduction system development protein phosphorylation regulation of mitotic nuclear division nuclear migration Rho protein signal transduction protein localization endosomal transport adherens junction organization establishment or maintenance of apical/basal cell polarity dendritic cell migration positive regulation of catalytic activity positive regulation of MAPK cascade positive regulation of neuron apoptotic process positive regulation of DNA replication positive regulation of JNK cascade filopodium assembly neuron fate determination nucleus localization positive regulation of synapse structural plasticity positive regulation of protein kinase B signaling heart contraction cellular response to interferon-gamma actin filament branching positive regulation of intracellular protein transport cell-cell adhesion regulation of modification of postsynaptic structure response to glucose regulation of exocytosis submandibular salivary gland formation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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