Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

SEMA3A Monoclonal Antibody (M317)

View all (21) SEMA3A antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

MA5-47732

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

M317

Immunogen

Clone M317 was generated from a synthetic peptide (coupled to carrier protein) corresponding to amino acids in the central region of human Sema3A. The sequence used is highly conserved in rat and mouse Sema3A, and has low homology to other semaphorin family members.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Amount

200 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA, 50% glycerol

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2942713

Product Specific Information

The antibody detects a 95kDa* protein corresponding to the apparent molecular mass of Sema3A on SDS-PAGE immunoblots of human recombinant Sema3A and adult mouse brain lysates.

Target Information

This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: collapsin 1; collapsin-1; MGC133243; sema D; sema domain, immunoglobulin domain (Ig), short basic domain, sec; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; sema III; semaphorin D; semaphorin III; semaphorin L; semaphorin-D; unnamed protein product

View more View less

Gene Aliases: coll-1; COLL1; HH16; Hsema-I; Hsema-III; SEMA1; SEMAD; SEMAIII; SEMAL; SemD

View more View less

UniProt ID: (Human) Q14563, (Rat) Q63548, (Mouse) O08665

View more View less

Entrez Gene ID: (Human) 10371, (Rat) 29751, (Mouse) 20346

View more View less

Function(s)
semaphorin receptor binding neuropilin binding chemorepellent activity receptor binding protein binding
Process(es)
neural crest cell migration neuron migration regulation of heart rate nervous system development axon guidance axonal fasciculation synaptic target recognition motor neuron axon guidance negative regulation of epithelial cell migration negative regulation of neuron projection development facial nerve structural organization trigeminal nerve structural organization nerve development olfactory bulb development branchiomotor neuron axon guidance gonadotrophin-releasing hormone neuronal migration to the hypothalamus regulation of anatomical structure morphogenesis positive regulation of cell migration negative regulation of axon extension ventral trunk neural crest cell migration dendrite morphogenesis regulation of axon extension involved in axon guidance negative regulation of axon extension involved in axon guidance axon extension involved in axon guidance negative chemotaxis negative regulation of developmental process negative regulation of multicellular organismal process axonogenesis involved in innervation dichotomous subdivision of terminal units involved in salivary gland branching sympathetic ganglion development trigeminal ganglion development semaphorin-plexin signaling pathway sympathetic neuron projection extension sympathetic neuron projection guidance maintenance of synapse structure regulation of plasma membrane bounded cell projection organization basal dendrite arborization neural crest cell migration involved in autonomic nervous system development neural crest cell migration involved in sympathetic nervous system development facioacoustic ganglion development positive regulation of male gonad development regulation of multicellular organismal development positive regulation of neuron migration forebrain development positive regulation of JNK cascade sympathetic nervous system development sensory system development
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support