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Invitrogen

NOTCH2 Chimeric Recombinant Mouse Monoclonal Antibody (B9)

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Product Details

MA5-47821

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-

Inhibition Assays (Inhibition)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

B9

Immunogen

NRR of mouse Notch 2.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3074268

Product Specific Information

Specificity: An engineered ScFv fragment antibody that binds to both mouse mNRR2 and human hNRR2 but not NRR1.

Target Information

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: membrane bound receptor; Motch B; notch 2; Notch gene homolog 2; Notch homolog 2; putative cell-fate determining protein; transmembrane protein; unnamed protein product

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Gene Aliases: AGS2; HJCYS; hN2; N2

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UniProt ID: (Human) Q04721, (Mouse) O35516

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Entrez Gene ID: (Human) 4853, (Mouse) 18129

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Function(s)
transcription coactivator activity calcium ion binding protein binding enzyme binding signaling receptor activity NF-kappaB binding
Process(es)
cell fate determination heart looping marginal zone B cell differentiation atrioventricular node development pulmonary valve morphogenesis regulation of transcription, DNA-templated apoptotic process Notch signaling pathway nervous system development axon guidance positive regulation of cell proliferation organ morphogenesis negative regulation of gene expression positive regulation of keratinocyte proliferation hemopoiesis cell differentiation intracellular signal transduction wound healing regulation of apoptotic process negative regulation of apoptotic process positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of Ras protein signal transduction bone remodeling regulation of developmental process positive regulation of smooth muscle cell differentiation cardiac septum morphogenesis atrial septum morphogenesis positive regulation of ERK1 and ERK2 cascade left/right axis specification cellular response to tumor cell proximal tubule development glomerular visceral epithelial cell development glomerular capillary formation positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of hemopoiesis regulation of osteoclast development negative regulation of transcription from RNA polymerase II promoter in utero embryonic development liver development placenta development morphogenesis of an epithelial sheet epithelial cell development inflammatory response to antigenic stimulus regulation of transcription from RNA polymerase II promoter humoral immune response determination of left/right symmetry positive regulation of cell development embryonic limb morphogenesis positive regulation of BMP signaling pathway activation of protein kinase B activity multicellular organism growth intrahepatic bile duct development epithelial cell differentiation involved in kidney development defense response to bacterium myeloid dendritic cell differentiation positive regulation of apoptotic process developmental growth placenta blood vessel development ciliary body morphogenesis nephron tubule development hepatocyte proliferation liver morphogenesis cholangiocyte proliferation
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