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Invitrogen

Complement C3b Monoclonal Antibody (2B10B9B2)

View all (15) Complement C3b antibodies

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Product Details

MA5-48993

Applications
Tested Dilution
Publications

Western Blot (WB)

1:50
-

Inhibition Assays (Inhibition)

1:50
-
Product Specifications

Species Reactivity

Rat

Host/Isotype

Mouse / IgM

Class

Monoclonal

Type

Antibody

Clone

2B10B9B2

Immunogen

The monoclonal antibody 2B10B9B2 reacts with an epitope on C3b

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

100 µg/mL

Amount

100 µg

Storage buffer

tissue culture supernatant

Contains

0.02% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3091129

Product Specific Information

The antibody reacts both with intact C3 and C3b.

Target Information

Inactive complement component 3b (iC3b) is a 42kDa neoantigen present in blood serum. Cleavage of C3b into iC3b by the protease factor I, in the presence of cofactors, changes the structure and resulting binding properties, preventing binding by complement factor B and properdin. This prevents further progression of the complement pathway, providing another mechanism by which the complement pathway may be regulated. iC3b is thought to play a role in inducing tolerance, binding complement receptor type 3 on antigen presenting cells and stimulating them to produce transforming growth factor beta2 and interleukin-10. It is thought to stimulate B-cells via the CD21 receptor providing a link between the innate and adaptive immune responses. Additionally iC3b acts as an opsonin which is recognised by complement receptor 3 expressed on leukocytes or complement receptor of the immunoglobulin superfamily (CRIg) on Kupffer cells, stimulating phagocytosis of the tagged cells. iC3b levels are often elevated in diseases such as Systemic Lupus Erythematosis and Rheumatoid arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C3 convertase cleavage product; complement component 3; complement component C3; iC3b; unnamed protein product

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UniProt ID: (Rat) P01026

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Entrez Gene ID: (Rat) 24232

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Function(s)
antigen binding endopeptidase inhibitor activity protein binding chemokine activity lipid binding C5L2 anaphylatoxin chemotactic receptor binding receptor agonist activity
Process(es)
positive regulation of type IIa hypersensitivity complement activation, lectin pathway positive regulation of protein phosphorylation positive regulation of activation of membrane attack complex complement receptor mediated signaling pathway tolerance induction proteolysis inflammatory response complement activation complement activation, alternative pathway complement activation, classical pathway opsonization response to xenobiotic stimulus response to bacterium positive regulation of vascular endothelial growth factor production positive regulation of glucose transport regulation of triglyceride biosynthetic process positive regulation of lipid storage neuron remodeling regulation of complement activation regulation of complement activation, alternative pathway leukocyte chemotaxis response to magnesium ion response to estradiol response to progesterone oviduct epithelium development vascular smooth muscle cell differentiation B cell activation response to estrogen innate immune response positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of angiogenesis positive regulation of receptor-mediated endocytosis positive regulation of developmental growth positive regulation of phagocytosis response to glucocorticoid retina development in camera-type eye positive regulation of phagocytosis, engulfment innervation positive regulation of ERK1 and ERK2 cascade positive regulation of glomerular mesangial cell proliferation beta-amyloid clearance complement-dependent cytotoxicity complement-mediated synapse pruning vertebrate eye-specific patterning complement activation, GZMK pathway positive regulation of opsonization positive regulation of sensory perception of pain negative regulation of vascular smooth muscle contraction positive regulation of apoptotic cell clearance
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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