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Invitrogen

PIN1 Monoclonal Antibody (5E5)

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PIN1 Monoclonal Antibody (5E5)

Product Details

MA5-49154

Applications
Tested Dilution
Publications

Western Blot (WB)

0.25-0.5 µg/mL
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Non-human primate, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

5E5

Immunogen

E.coli-derived human Pin1 recombinant protein (Position: M1-E163).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3074812

Product Specific Information

Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Human Pin1 shares 95% amino acid (aa) sequence identity with mouse Pin1.

Positive Control - WB: human Hela whole cell, human HEK293 whole cell, human SW620 whole cell, monkey COS-7 whole cell, rat brain tissue, rat C6 whole cell. ICC/IF: Hela cell. Flow: U87 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

PIN1 (Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1) is a Protein Coding gene. Diseases associated with PIN1 include Meibomian Cyst and Viral Exanthem. Among its related pathways are Transport of the SLBP independent Mature mRNA and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and mitogen-activated protein kinase binding.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ARABIDOPSIS THALIANA PIN-FORMED 1; ATPIN1; EC 5.2.1.8; F6D5.2; F6D5_2; NIMA-interacting; parvulin PIN1; PIN-FORMED 1; PPIase Pin1; prolyl isomerase; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1; protein interacting with never in mitosis A1; rotamase Pin1; UBL5; unnamed protein product

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Gene Aliases: DOD; UBL5

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UniProt ID: (Human) Q13526

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Entrez Gene ID: (Human) 5300, (Rat) 298696

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Function(s)
peptidyl-prolyl cis-trans isomerase activity motor activity protein binding beta-catenin binding cis-trans isomerase activity mitogen-activated protein kinase kinase binding GTPase activating protein binding tau protein binding phosphoserine binding phosphothreonine binding phosphoprotein binding ubiquitin ligase activator activity isomerase activity
Process(es)
protein peptidyl-prolyl isomerization response to hypoxia positive regulation of protein phosphorylation Rho protein signal transduction regulation of gene expression neuron differentiation negative regulation of transforming growth factor beta receptor signaling pathway regulation of protein stability protein destabilization regulation of cytokinesis regulation of cell proliferation negative regulation of protein catabolic process negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter microtubule polymerization synapse organization protein stabilization negative regulation of SMAD protein import into nucleus positive regulation of cell growth involved in cardiac muscle cell development negative regulation of ERK1 and ERK2 cascade protein localization to mitochondrion cellular response to hypoxia positive regulation of canonical Wnt signaling pathway regulation protein catabolic process at postsynapse regulation of protein localization to nucleus negative regulation of beta-amyloid formation negative regulation of brown fat cell differentiation negative regulation of cell motility regulation of mitotic nuclear division
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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