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Invitrogen

RBPJ Monoclonal Antibody (6G4)

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RBPJ Monoclonal Antibody (6G4)

Product Details

MA5-49168

Applications
Tested Dilution
Publications

Western Blot (WB)

0.25-0.5 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

6G4

Immunogen

E.coli-derived human RBPJK/RBPJ recombinant protein (Position: K41-Q467).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3074826

Product Specific Information

Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Positive Control - WB: human HEK293 whole cell, human HEPG2 whole cell, human HELA whole cell, human MCF-7 whole cell, human U87 whole cell, human HL-60 whole cell, rat NRK whole cell, mouse smooth muscle tissue. Flow: HEPA1-6 cell, U937 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

CSL plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. The protein is abundantly expressed in heart and skeletal muscle and expression is increased by passive stretch. Mutations in this gene can lead to X-linked deafness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CSL family DNA binding factor 1; H-2K binding factor-2; immunoglobulin kappa J region recombination signal binding protein 1; J-kappa recombination signal binding protein; Jkappa recombination signal binding protein; rbp-jkappa; renal carcinoma antigen NY-REN-30; suppressor of hairless homolog; unnamed protein product

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Gene Aliases: AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1; Igkrsbp; KBF2; RBP-J; RBP-J kappa; RBP-JK; RBP-Jkappa; RBPJK; RBPSUH; SUH

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UniProt ID: (Human) Q06330, (Mouse) P31266

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Entrez Gene ID: (Human) 3516, (Mouse) 19664, (Rat) 679028

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding DNA-binding transcription factor binding macromolecular complex binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis somitogenesis epithelial to mesenchymal transition heart looping blood vessel remodeling inflammatory response to antigenic stimulus heart induction secondary heart field specification outflow tract morphogenesis endocardium development endocardium morphogenesis aortic valve development pulmonary valve development epithelial to mesenchymal transition involved in endocardial cushion formation cardiac left ventricle morphogenesis ventricular trabecula myocardium morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter humoral immune response Notch signaling pathway positive regulation of transcription of Notch receptor target heart development positive regulation of cell proliferation negative regulation of cell proliferation auditory receptor cell fate commitment epidermal cell fate specification regulation of gene expression positive regulation of gene expression negative regulation of neuron projection development negative regulation of smooth muscle cell migration pituitary gland development hemopoiesis neuron differentiation B cell differentiation keratinocyte differentiation negative regulation of ossification positive regulation of BMP signaling pathway negative regulation of smooth muscle cell apoptotic process somatic stem cell population maintenance dorsal aorta morphogenesis atrioventricular canal development regulation of cell proliferation defense response to bacterium myeloid dendritic cell differentiation regulation of generation of precursor metabolites and energy cell fate commitment negative regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of timing of cell differentiation animal organ development positive regulation of smooth muscle cell proliferation sebaceous gland development hair follicle maturation artery morphogenesis positive regulation of cardiac muscle cell proliferation cardiac muscle cell myoblast differentiation ventricular septum morphogenesis Clara cell differentiation labyrinthine layer blood vessel development arterial endothelial cell fate commitment regulation of cell adhesion involved in heart morphogenesis determination of heart left/right asymmetry blood vessel lumenization positive regulation of canonical Wnt signaling pathway blood vessel endothelial cell fate specification negative regulation of cold-induced thermogenesis positive regulation of ERBB signaling pathway positive regulation of ephrin receptor signaling pathway positive regulation of cell proliferation involved in heart morphogenesis
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