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Invitrogen

RAB11A Monoclonal Antibody (4H9)

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RAB11A Monoclonal Antibody (4H9)

Product Details

MA5-49197

Applications
Tested Dilution
Publications

Western Blot (WB)

0.25-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2-5 µg/mL
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

4H9

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Rab11A (171-211aa EIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQ).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3074855

Product Specific Information

Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Immunogen sequence is identical to the related mouse and rat sequences.

Positive Control - WB: human 293T whole cell, human SH-SY5Y whole cell, human MCF-7 whole cell, human Hela whole cell, rat brain tissue, rat PC-12 whole cell, mouse brain tissue, mouse Neuro-2a whole cell. IHC: human spleen tissue, human gastric carcinoma tissue, human placenta tissue. ICC/IF: T-47D cell. Flow: ANA-1 cell, RH35 cell, U937 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 24KG; GTPase; RAB 11A, member oncogene family; rab-11; RAB11A; unnamed protein product

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Gene Aliases: YL8

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UniProt ID: (Human) P62491, (Mouse) P62492, (Rat) P62494

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Entrez Gene ID: (Human) 8766, (Mouse) 53869, (Rat) 81830

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Function(s)
GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding microtubule binding myosin V binding dynein light intermediate chain binding protein domain specific binding
Process(es)
exocytosis microtubule-based movement mitotic metaphase plate congression positive regulation of epithelial cell migration positive regulation of G2/M transition of mitotic cell cycle vesicle-mediated transport astral microtubule organization neuron projection development melanosome transport endocytic recycling regulation of cytokinesis protein localization to cell surface multivesicular body assembly Golgi to plasma membrane protein transport positive regulation of cilium assembly regulation of long-term neuronal synaptic plasticity regulation of protein transport establishment of vesicle localization regulation of vesicle-mediated transport protein localization to cilium protein transmembrane transport establishment of protein localization to organelle protein localization to plasma membrane establishment of protein localization to membrane mitotic spindle assembly neurotransmitter receptor transport, endosome to postsynaptic membrane vesicle-mediated transport in synapse synaptic vesicle endosomal processing amyloid-beta clearance by transcytosis regulation of cilium assembly positive regulation of protein localization to plasma membrane positive regulation of mitotic cytokinetic process regulation of protein localization to centrosome protein localization to cleavage furrow exosomal secretion regulation of endocytic recycling plasma membrane to endosome transport vesicle-mediated transport to the plasma membrane intracellular cholesterol transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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