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Invitrogen
GLT-1 Recombinant Rabbit Monoclonal Antibody (28F9)
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FIGURE: 1 / 2
GLT-1 Antibody (MA5-50129) in WB
Western blot analysis of GLT-1 in U251 whole cell lysate using a dilution of 1:1,000. Samples were incubated with GLT-1 monoclonal antibody (Product # MA5-50129). Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution. Predicted band size: 62 kDa. Observed band size: 62 kDa.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-50129
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
28F9
Immunogen
A synthesized peptide derived from Human SLC1A2
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2 mg/mL
Amount
200 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Excitatory amino acid transporter 2 (EAAT2) is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis (ALS.) Alternatively spliced transcript variants of this gene have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EAAT2; excitotoxic amino acid transporter 2; GLT1a; GLT1b; GLT1c; glutamate transporter-1; glutamate/aspartate transporter II; human brain glutamate transporter; OTTHUMP00000165209; OTTHUMP00000165210; sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; unnamed protein product
Gene Aliases: DEE41; EAAT2; EIEE41; GLT-1; GLT1; HBGT
UniProt ID: (Human) P43004
Entrez Gene ID: (Human) 6506
L-glutamate transmembrane transporter activity
high-affinity glutamate transmembrane transporter activity
protein binding
anion transmembrane transporter activity
neutral amino acid transmembrane transporter activity
symporter activity
glutamate:sodium symporter activity
cysteine transmembrane transporter activity
glutathione biosynthetic process
neurotransmitter transport
amino acid transport
chemical synaptic transmission
neutral amino acid transport
L-glutamate transport
protein homotrimerization
transepithelial transport
L-aspartate transmembrane transport
D-aspartate import
cellular response to cocaine
glutamate homeostasis
anion transmembrane transport
import into cell
L-glutamate import across plasma membrane
neurotransmitter reuptake
L-aspartate import across plasma membrane
transport across blood-brain barrier
cysteine transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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